ITPR3 Antikörper (AA 22-230)

Produktnummer ABIN967898

Produktdetails anti-ITPR3 Antikörper

Target: ITPR3 (Inositol 1,4,5-Trisphosphate Receptor, Type 3 (ITPR3))

Bindungsspezifität: AA 22-230

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ITPR3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Kreuzreaktivität: Rind (Kuh), Hund, Maus, Ratte (Rattus)

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human IP3R-3 aa. 22-230

Klon: 2-IP3R

Isotyp: IgG2a

Anwendungsinformationen

Kommentare:

Related Products: ABIN968535, ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20° C.

Referenzen für anti-ITPR3 Antikörper (ABIN967898)

Leite, Thrower, Echevarria, Koulen, Hirata, Bennett, Ehrlich, Nathanson: "Nuclear and cytosolic calcium are regulated independently." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 5, pp. 2975-80, (2003) (PubMed).

Zanner, Hapfelmeier, Gratzl, Prinz: "Intracellular signal transduction during gastrin-induced histamine secretion in rat gastric ECL cells." in: American journal of physiology. Cell physiology, Vol. 282, Issue 2, pp. C374-82, (2002) (PubMed).

Pin, Rukstalis, Johnson, Konieczny: "The bHLH transcription factor Mist1 is required to maintain exocrine pancreas cell organization and acinar cell identity." in: The Journal of cell biology, Vol. 155, Issue 4, pp. 519-30, (2001) (PubMed).

Maranto: "Primary structure, ligand binding, and localization of the human type 3 inositol 1,4,5-trisphosphate receptor expressed in intestinal epithelium." in: The Journal of biological chemistry, Vol. 269, Issue 2, pp. 1222-30, (1994) (PubMed).

Blondel, Takeda, Janssen, Seino, Bell: "Sequence and functional characterization of a third inositol trisphosphate receptor subtype, IP3R-3, expressed in pancreatic islets, kidney, gastrointestinal tract, and other tissues." in: The Journal of biological chemistry, Vol. 268, Issue 15, pp. 11356-63, (1993) (PubMed).

Details zu ITPR3

Target: ITPR3 (Inositol 1,4,5-Trisphosphate Receptor, Type 3 (ITPR3))

Andere Bezeichnung: IP 3R-3 (ITPR3 Produkte)

Synonyme: Ip3r3 antikoerper, Itpr-3 antikoerper, IP3R antikoerper, IP3R3 antikoerper, IP3R3X antikoerper, inositol 1,4,5-triphosphate receptor 3 antikoerper, inositol 1,4,5-trisphosphate receptor type 3 antikoerper, inositol 1,4,5-trisphosphate receptor, type 3 antikoerper, Itpr3 antikoerper, ITPR3 antikoerper

Hintergrund: Inositol 1,4,5-triphosphate (IP3) functions as a second messenger for many hormones, growth factors, and neurotransmitters. IP3 causes the release of Ca2+ from intracellular stores by binding specific receptors that are coupled to Ca2+ channels. A number of studies have identified a family of at least four IP3 receptors (IP3R). The type III receptor (IP3R-3) has been isolated and characterized in human and rat. IP3 receptors are commonly localized in the endoplasmic reticulum, but have also been identified in the nucleus and the plasma membrane. Co-expression of different IP3 receptors is detected in most tissues and cell lines. Although these receptors appear to have a similar specificity for inositol phosphates, the different receptors have been reported to have different affinities for IP3 as follows: type II > type I > type III. This antibody is routinely tested by western blot analysis.
Synonyms: Inositol 1,4,5-triphosphate receptor type III

Molekulargewicht: 300 kDa

Pathways: Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, BCR Signaling