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STAT5A Antikörper (AA 451-649)

STAT5A Reaktivität: Human, Maus, Ratte, Hund WB, IHC, IF, IP Wirt: Maus Monoclonal 89-Stat5 unconjugated
Produktnummer ABIN967811
  • Target Alle STAT5A Antikörper anzeigen
    STAT5A (Signal Transducer and Activator of Transcription 5A (STAT5A))
    Bindungsspezifität
    • 56
    • 24
    • 17
    • 15
    • 15
    • 14
    • 9
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 451-649
    Reaktivität
    • 204
    • 109
    • 82
    • 25
    • 14
    • 9
    • 8
    • 6
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte, Hund
    Wirt
    • 178
    • 29
    • 2
    Maus
    Klonalität
    • 158
    • 51
    Monoklonal
    Konjugat
    • 118
    • 10
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser STAT5A Antikörper ist unkonjugiert
    Applikation
    • 162
    • 69
    • 58
    • 40
    • 39
    • 30
    • 24
    • 22
    • 20
    • 13
    • 10
    • 8
    • 8
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
    Kreuzreaktivität
    Human, Hund, Maus, Ratte (Rattus)
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Sheep Stat5 aa. 451-649
    Klon
    89-Stat5
    Isotyp
    IgG2b
    Top Product
    Discover our top product STAT5A Primärantikörper
  • Kommentare

    Related Products: ABIN968536, ABIN967389

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20° C.
  • Buitenhuis, Baltus, Lammers, Coffer, Koenderman: "Signal transducer and activator of transcription 5a (STAT5a) is required for eosinophil differentiation of human cord blood-derived CD34+ cells." in: Blood, Vol. 101, Issue 1, pp. 134-42, (2002) (PubMed).

    Chughtai, Schimchowitsch, Lebrun, Ali: "Prolactin induces SHP-2 association with Stat5, nuclear translocation, and binding to the beta-casein gene promoter in mammary cells." in: The Journal of biological chemistry, Vol. 277, Issue 34, pp. 31107-14, (2002) (PubMed).

    Sadowski, Choi, Le, Wheeler, Wang, Sadowski: "Insulin Induction of SOCS-2 and SOCS-3 mRNA expression in C2C12 Skeletal Muscle Cells Is Mediated by Stat5*." in: The Journal of biological chemistry, Vol. 276, Issue 23, pp. 20703-10, (2001) (PubMed).

    Kirken, Malabarba, Xu, Liu, Farrar, Hennighausen, Larner, Grimley, Rui: "Prolactin stimulates serine/tyrosine phosphorylation and formation of heterocomplexes of multiple Stat5 isoforms in Nb2 lymphocytes." in: The Journal of biological chemistry, Vol. 272, Issue 22, pp. 14098-103, (1997) (PubMed).

    Gouilleux, Wakao, Mundt, Groner: "Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription." in: The EMBO journal, Vol. 13, Issue 18, pp. 4361-9, (1994) (PubMed).

  • Target
    STAT5A (Signal Transducer and Activator of Transcription 5A (STAT5A))
    Andere Bezeichnung
    Stat5 (STAT5A Produkte)
    Synonyme
    MGF antikoerper, STAT5 antikoerper, AA959963 antikoerper, Stat5 antikoerper, STAT5A/MGF antikoerper, STATA5 antikoerper, STAT5A antikoerper, stat5 antikoerper, stat5b antikoerper, signal transducer and activator of transcription 5A antikoerper, signal transducer and activator of transcription 5a antikoerper, STAT5A antikoerper, Stat5a antikoerper, stat5a antikoerper, LOC100348518 antikoerper, LOC100716811 antikoerper
    Hintergrund
    Stat5, also known as mammary gland factor (MGF) has been shown to play a critical role in the lactogenic hormone response and has been well characterized in mammary epithelial cells. The SH3 domain of MGF shows extensive homology with the SH2 domains of Stat1 and Stat2. This homology has led to its classification as a member of the Stat family. The Stat proteins function both as cytoplasmic signal transducers and as activators of transcription. Stat (Signal transducer and activators of transcription) proteins are critical mediators of the biologic activity of cytokines, including interleukins, interferons, erythropoietin, and growth factors. Ligand-receptor interaction leads to activation of constitutively associated JAK family kinases and subsequent recruitment and activation of Stat proteins by tyrosine phosphorylation. Active Stat proteins then move to the nucleus to promote transcription of cytokine-inducible genes. Stat5a has been shown to be involved in lactogenesis and mammary development, while Stat5b has been shown to be involved in growth hormone signaling and to play a role in liver gene expression. Stat5 activity is tightly regulated throughout gestation, lactation, and post-lactation.
    Synonyms: MGF
    Molekulargewicht
    92 kDa
    Pathways
    JAK-STAT Signalweg, RTK Signalweg, Response to Growth Hormone Stimulus, C21-Steroid Hormone Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Activated T Cell Proliferation
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