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E-cadherin Antikörper (C-Term)

CDH1 Reaktivität: Human, Maus, Ratte, Hund WB, IHC, IF, IP Wirt: Maus Monoclonal 36-E unconjugated
Produktnummer ABIN967800
  • Target Alle E-cadherin (CDH1) Antikörper anzeigen
    E-cadherin (CDH1) (Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1))
    Bindungsspezifität
    • 17
    • 17
    • 16
    • 16
    • 15
    • 15
    • 8
    • 8
    • 7
    • 7
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 250
    • 102
    • 86
    • 18
    • 17
    • 15
    • 9
    • 9
    • 9
    • 6
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte, Hund
    Wirt
    • 202
    • 82
    • 8
    • 7
    Maus
    Klonalität
    • 188
    • 110
    • 1
    Monoklonal
    Konjugat
    • 140
    • 36
    • 29
    • 10
    • 10
    • 9
    • 8
    • 8
    • 7
    • 6
    • 6
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser E-cadherin Antikörper ist unkonjugiert
    Applikation
    • 206
    • 94
    • 91
    • 68
    • 56
    • 55
    • 39
    • 35
    • 29
    • 27
    • 17
    • 16
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
    Kreuzreaktivität
    Hund, Maus, Ratte (Rattus)
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human E-Cadherin C-terminal Recombinant Protein
    Klon
    36-E
    Isotyp
    IgG2a kappa
    Top Product
    Discover our top product CDH1 Primärantikörper
  • Kommentare

    Related Products: ABIN968533, ABIN967389

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20°C.
  • Chua, Nivison-Smith, Fletcher, Trenholm, Awatramani, Kalloniatis: "Early remodeling of Müller cells in the rd/rd mouse model of retinal dystrophy." in: The Journal of comparative neurology, Vol. 521, Issue 11, pp. 2439-53, (2014) (PubMed).

    Burns, Collado, Oliver, Corwin: "Specializations of intercellular junctions are associated with the presence and absence of hair cell regeneration in ears from six vertebrate classes." in: The Journal of comparative neurology, Vol. 521, Issue 6, pp. 1430-48, (2013) (PubMed).

    Brusés: "N-cadherin regulates primary motor axon growth and branching during zebrafish embryonic development." in: The Journal of comparative neurology, Vol. 519, Issue 9, pp. 1797-815, (2012) (PubMed).

    Akins, Benson, Greer: "Cadherin expression in the developing mouse olfactory system." in: The Journal of comparative neurology, Vol. 501, Issue 4, pp. 483-97, (2007) (PubMed).

    Weng, Xin, Pablo, Grueneberg, Hagel, Bain, Müller, Papkoff: "Protection against anoikis and down-regulation of cadherin expression by a regulatable beta-catenin protein." in: The Journal of biological chemistry, Vol. 277, Issue 21, pp. 18677-86, (2002) (PubMed).

    Miyoshi, Shillingford, Smith, Grimm, Wagner, Oka, Rosen, Robinson, Hennighausen: "Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium." in: The Journal of cell biology, Vol. 155, Issue 4, pp. 531-42, (2001) (PubMed).

    Sheibani, Sorenson, Frazier: "Differential modulation of cadherin-mediated cell-cell adhesion by platelet endothelial cell adhesion molecule-1 isoforms through activation of extracellular regulated kinases." in: Molecular biology of the cell, Vol. 11, Issue 8, pp. 2793-802, (2000) (PubMed).

    Jaksits, Kriehuber, Charbonnier, Rappersberger, Stingl, Maurer: "CD34+ cell-derived CD14+ precursor cells develop into Langerhans cells in a TGF-beta 1-dependent manner." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 163, Issue 9, pp. 4869-77, (1999) (PubMed).

  • Target
    E-cadherin (CDH1) (Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1))
    Andere Bezeichnung
    E-Cadherin (CDH1 Produkte)
    Synonyme
    Arc-1 antikoerper, CD324 antikoerper, CDHE antikoerper, ECAD antikoerper, LCAM antikoerper, UVO antikoerper, E-cadherin antikoerper, cdh1 antikoerper, si:dz180o5.2 antikoerper, uvo antikoerper, lcam antikoerper, E-Cad antikoerper, XBcad antikoerper, l-cam antikoerper, xcdh1 antikoerper, cdhc-A antikoerper, xb-cad antikoerper, XTCAD-1 antikoerper, c-cadherin antikoerper, cadherin-1 antikoerper, uvomorulin antikoerper, XB-cadherin antikoerper, arc-1 antikoerper, cd324 antikoerper, cdhe antikoerper, ecad antikoerper, AA960649 antikoerper, E-cad antikoerper, Ecad antikoerper, L-CAM antikoerper, Um antikoerper, cadherin 1 antikoerper, si:busm1-180o5.2 antikoerper, cadherin 1, type 1, E-cadherin (epithelial) antikoerper, cadherin 1, type 1 S homeolog antikoerper, CDH1 antikoerper, si:busm1-180o5.2 antikoerper, cdh1 antikoerper, Cdh1 antikoerper, cdh1.S antikoerper
    Hintergrund
    E-Cadherin is a 120-kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with cortical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression. The 36/E-Cadherin monoclonal antibody recognizes the cytoplasmic domain of E-Cadherin, regardless of phosphorylation status. The peptide immunogen was generated from human E-Cadherin aa. 735-883.
    Synonyms: CD324, CDH1, CADH1, Cadherin-1, ECAD, CDHE, Arc-1, LCAM, UVO, Uvomorulin
    Molekulargewicht
    120 kDa
    Pathways
    WNT Signalweg, Sensory Perception of Sound, Cell-Cell Junction Organization, Tube Formation
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