RAB27A Antikörper

Produktnummer ABIN967619

Produktdetails anti-RAB27A Antikörper

Target: RAB27A (RAB27A, Member RAS Oncogene Family (RAB27A))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser RAB27A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Marke: BD Pharmingen™

Produktmerkmale: 1. Please refer to us for technical protocols.
2. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human Rab27A

Klon: 20-RAB27

Isotyp: IgG1 kappa

Anwendungsinformationen

Kommentare:

Related Products: ABIN967389, ABIN968587

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C.

Referenzen für anti-RAB27A Antikörper (ABIN967619)

Yoon, Kovalenko, Bogdanov, Wallach: "MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation." in: Immunity, Vol. 47, Issue 1, pp. 51-65.e7, (2017) (PubMed).

Hong: "Cytotoxic T lymphocyte exocytosis: bring on the SNAREs!" in: Trends in cell biology, Vol. 15, Issue 12, pp. 644-50, (2005) (PubMed).

Fukuda: "Versatile role of Rab27 in membrane trafficking: focus on the Rab27 effector families." in: Journal of biochemistry, Vol. 137, Issue 1, pp. 9-16, (2005) (PubMed).

Izumi, Gomi, Kasai, Mizutani, Torii: "The roles of Rab27 and its effectors in the regulated secretory pathways." in: Cell structure and function, Vol. 28, Issue 5, pp. 465-74, (2004) (PubMed).

Details zu RAB27A

Target: RAB27A (RAB27A, Member RAS Oncogene Family (RAB27A))

Andere Bezeichnung: RAB27 (RAB27A Produkte)

Synonyme: MGC80943 antikoerper, RAB27A antikoerper, gs2 antikoerper, ram antikoerper, rab27 antikoerper, MGC89827 antikoerper, hst18676 antikoerper, zgc:114135 antikoerper, GS2 antikoerper, HsT18676 antikoerper, RAB27 antikoerper, RAM antikoerper, 2210402C08Rik antikoerper, 2410003M20Rik antikoerper, 4933437C11Rik antikoerper, ash antikoerper, RAB27A, member RAS oncogene family L homeolog antikoerper, RAB27A, member RAS oncogene family antikoerper, RAB27A, member RAS oncogene family S homeolog antikoerper, rab27a.L antikoerper, RAB27A antikoerper, rab27a antikoerper, rab27a.S antikoerper, Rab27a antikoerper

Hintergrund: Members of the Rab family of GTPases are non-transforming, membrane-bound, geranylgeranylated members of the Ras superfamily that are involved in the fusion and trafficking of cellular vesicles. Rab27A is expressed in many human tissues and it regulates the secreation of several types of cellular vesicles, such as melanosomes, insulin granules of pancreatic beta cells, and lytic granules of cytotoxic T lymphocytes. Rab27A is able to regulate such diverse processes by interacting with organelle-specific effector proteins, including melanophilin, granuphilin, and Munc13-4, respectively. Defects in Rab27A function are associated with the human diseases choroideremia and Griscelli syndrome 2 and the ashen mutant mouse. Rab27B is not so widely expressed, yet it is reported to have similar functional capacities as Rab27A.

Molekulargewicht: 25 kDa

Pathways: Peptide Hormone Metabolism