STAT2 Antikörper (pTyr690)

Produktnummer ABIN967579

Produktdetails anti-STAT2 Antikörper

Target: STAT2 (Signal Transducer and Activator of Transcription 2, 113kDa (STAT2))

Bindungsspezifität: pTyr690

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser STAT2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Marke: BD Pharmingen™

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Phosphorylated Human Stat2 Peptide

Klon: 7a-Stat2

Isotyp: IgG1 kappa

Anwendungsinformationen

Kommentare:

Related Products: ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C.

Referenzen für anti-STAT2 Antikörper (ABIN967579)

Bromberg, Darnell: "The role of STATs in transcriptional control and their impact on cellular function." in: Oncogene, Vol. 19, Issue 21, pp. 2468-73, (2000) (PubMed).

Heim: "The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus." in: European journal of clinical investigation, Vol. 26, Issue 1, pp. 1-12, (1996) (PubMed).

Details zu STAT2

Target: STAT2 (Signal Transducer and Activator of Transcription 2, 113kDa (STAT2))

Andere Bezeichnung: Stat2 (STAT2 Produkte)

Synonyme: wu:fj84d07 antikoerper, p113 antikoerper, stat2 antikoerper, 1600010G07Rik antikoerper, AW496480 antikoerper, ISGF-3 antikoerper, P113 antikoerper, STAT113 antikoerper, signal transducer and activator of transcription 2 antikoerper, AGAP000099-PA antikoerper, stat2 antikoerper, STAT2 antikoerper, Stat2 antikoerper

Hintergrund: Stat (Signal transducer and activators of transcription) proteins are critical mediators of the biologic activity of cytokines, including interleukins, interferons, erythropoietin, and growth factors. Ligand-receptor interaction leads to activation of constitutively associated JAK family kinases and subsequent recruitment/activation of Stat proteins by tyrosine phosphorylation. Active Stat proteins then move to the nucleus to promote transcription of cytokine-inducible genes. Seven Stat proteins have been cloned, each of which is differentially expressed and/or activated in a cytokine-specific and cell type-specific manner. Stat1 and Stat2 are components of the ISGF3 (Interferon-Stimulated Gene Factor 3) complex, which is the primary transcription activator induced by the binding of the interferon to a specific cell-surface receptor. Stat2 is a 113-kDa protein having approximately 40% homology with Stat1a. Stat2 interacts with Stat1 for the efficient activation of Stat1 in response to IFN-a, which is essential for normal transcriptional activity of the ISGF3 complex. Stat2 phosphorylation at the tyrosine 690 residue (Y690) after IFN-a activation can occur independently of Stat1, but the localization and nuclear stability of phosphorylated Stat2 is dependent on Stat1.
The 7a/Stat2 monoclonal antibody recognizes the phosphorylated Y690 of human Stat2.

Molekulargewicht: 113 kDa

Pathways: JAK-STAT Signalweg, Hepatitis C, CXCR4-mediated Signaling Events