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CD74 Antikörper

CD74 Reaktivität: Maus WB, IF, IP, IHC (f), IHC (fro), IHC (zinc), ICS Wirt: Ratte Monoclonal In-1 unconjugated
Produktnummer ABIN967482
  • Target Alle CD74 Antikörper anzeigen
    CD74 (HLA-DR-gamma (CD74))
    Reaktivität
    • 185
    • 64
    • 13
    • 11
    Maus
    Wirt
    • 123
    • 80
    • 3
    • 2
    Ratte
    Klonalität
    • 139
    • 67
    • 2
    Monoklonal
    Konjugat
    • 70
    • 17
    • 16
    • 10
    • 10
    • 7
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Dieser CD74 Antikörper ist unkonjugiert
    Applikation
    • 126
    • 112
    • 79
    • 45
    • 38
    • 36
    • 30
    • 26
    • 18
    • 14
    • 13
    • 11
    • 9
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Zinc-fixed Sections) (IHC (zinc)), Intracellular Staining (ICS)
    Marke
    BD Pharmingen™
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    A.TL mouse lymphocytes and B10.A mouse-derived CH1 B-cell lymphoma
    Klon
    In-1
    Isotyp
    IgG2b kappa
    Top Product
    Discover our top product CD74 Primärantikörper
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.5 mg/mL
    Buffer
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store undiluted at 4°C.
  • Nakagawa, Roth, Wong, Nelson, Farr, Deussing, Villadangos, Ploegh, Peters, Rudensky: "Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus." in: Science (New York, N.Y.), Vol. 280, Issue 5362, pp. 450-3, (1998) (PubMed).

    Bertolino, Rabourdin-Combe: "The MHC class II-associated invariant chain: a molecule with multiple roles in MHC class II biosynthesis and antigen presentation to CD4+ T cells." in: Critical reviews in immunology, Vol. 16, Issue 4, pp. 359-79, (1997) (PubMed).

    Shachar, Flavell: "Requirement for invariant chain in B cell maturation and function." in: Science (New York, N.Y.), Vol. 274, Issue 5284, pp. 106-8, (1996) (PubMed).

    Bodmer, Viville, Benoist, Mathis: "Diversity of endogenous epitopes bound to MHC class II molecules limited by invariant chain." in: Science (New York, N.Y.), Vol. 263, Issue 5151, pp. 1284-6, (1994) (PubMed).

    Cresswell: "Assembly, transport, and function of MHC class II molecules." in: Annual review of immunology, Vol. 12, pp. 259-93, (1994) (PubMed).

    Elliott, Drake, Amigorena, Elsemore, Webster, Mellman, Flavell: "The invariant chain is required for intracellular transport and function of major histocompatibility complex class II molecules." in: The Journal of experimental medicine, Vol. 179, Issue 2, pp. 681-94, (1994) (PubMed).

    Bikoff, Huang, Episkopou, van Meerwijk, Germain, Robertson: "Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression." in: The Journal of experimental medicine, Vol. 177, Issue 6, pp. 1699-712, (1993) (PubMed).

    Naujokas, Morin, Anderson, Peterson, Miller: "The chondroitin sulfate form of invariant chain can enhance stimulation of T cell responses through interaction with CD44." in: Cell, Vol. 74, Issue 2, pp. 257-68, (1993) (PubMed).

    Viville, Neefjes, Lotteau, Dierich, Lemeur, Ploegh, Benoist, Mathis: "Mice lacking the MHC class II-associated invariant chain." in: Cell, Vol. 72, Issue 4, pp. 635-48, (1993) (PubMed).

    Mehringer, Harris, Kindle, McCourt, Cullen: "Characterization of fragments of the murine Ia-associated invariant chain." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 146, Issue 3, pp. 920-7, (1991) (PubMed).

    Koch, Koch, Hämmerling: "Ia invariant chain detected on lymphocyte surfaces by monoclonal antibody." in: Nature, Vol. 299, Issue 5884, pp. 644-5, (1982) (PubMed).

  • Target
    CD74 (HLA-DR-gamma (CD74))
    Andere Bezeichnung
    CD74 (CD74 Produkte)
    Synonyme
    DHLAG antikoerper, HLADG antikoerper, II antikoerper, Ia-GAMMA antikoerper, CLIP antikoerper, Ii antikoerper, INVG34 antikoerper, Iclp-1 antikoerper, iclp1 antikoerper, wu:fb11f09 antikoerper, wu:fb12a01 antikoerper, wu:fb13d06 antikoerper, wu:fk94e07 antikoerper, Iclp-2 antikoerper, cd74 antikoerper, iclp2 antikoerper, zgc:123161 antikoerper, CD74 molecule antikoerper, CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) antikoerper, CD74 molecule, major histocompatibility complex, class II invariant chain a antikoerper, CD74 molecule, major histocompatibility complex, class II invariant chain b antikoerper, CD74 antikoerper, Cd74 antikoerper, cd74a antikoerper, cd74b antikoerper
    Hintergrund
    The In-1 antibody reacts with CD74, the MHC class II-associated Invariant chain (Ii), expressed in I-A+ cell populations. Although it is predominantly expressed intracellularly, it has also been detected on the cell surface of some B-cell lines and at low levels on a small number of B lymphocytes. In the mouse, alternatively spliced transcripts encode 31-kDa and 41-kDa isoforms, and the cell-surface CD74 has a chondroitin sulfate side chain which allows it to interact with CD44. CD74 is directly involved in the intracellular transport of MHC class II molecules and antigen presentation, and it affects the maturation of T and B lymphocytes.
    Synonyms: Ii
    Pathways
    Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Negative Regulation of intrinsic apoptotic Signaling, Cancer Immune Checkpoints
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