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CD19 Antikörper

CD19 Reaktivität: Maus FACS, IP, IHC (fro), Func Wirt: Ratte Monoclonal 1D3 unconjugated
Produktnummer ABIN967381
  • Target Alle CD19 Antikörper anzeigen
    CD19 (CD19 Molecule (CD19))
    Reaktivität
    • 305
    • 180
    • 48
    • 30
    • 19
    • 10
    • 7
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Maus
    Wirt
    • 185
    • 141
    • 63
    • 4
    Ratte
    Klonalität
    • 261
    • 128
    • 2
    Monoklonal
    Konjugat
    • 118
    • 25
    • 22
    • 21
    • 18
    • 9
    • 9
    • 9
    • 8
    • 8
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CD19 Antikörper ist unkonjugiert
    Applikation
    • 274
    • 121
    • 75
    • 66
    • 61
    • 43
    • 23
    • 21
    • 17
    • 14
    • 14
    • 10
    • 10
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func)
    Marke
    BD Pharmingen™
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Mouse CD19 Transfected Cell Line
    Klon
    1D3
    Isotyp
    IgG2a kappa
    Top Product
    Discover our top product CD19 Primärantikörper
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.5 mg/mL
    Buffer
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store undiluted at 4° C.
  • Gommerman, Oh, Zhou, Tedder, Maurer, Galli, Carroll: "A role for CD21/CD35 and CD19 in responses to acute septic peritonitis: a potential mechanism for mast cell activation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 12, pp. 6915-21, (2000) (PubMed).

    Sato, Jansen, Tedder: "CD19 and CD22 expression reciprocally regulates tyrosine phosphorylation of Vav protein during B lymphocyte signaling." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 24, pp. 13158-62, (1998) (PubMed).

    Inaoki, Sato, Weintraub, Goodnow, Tedder: "CD19-regulated signaling thresholds control peripheral tolerance and autoantibody production in B lymphocytes." in: The Journal of experimental medicine, Vol. 186, Issue 11, pp. 1923-31, (1997) (PubMed).

    Sato, Miller, Howard, Tedder: "Regulation of B lymphocyte development and activation by the CD19/CD21/CD81/Leu 13 complex requires the cytoplasmic domain of CD19." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 159, Issue 7, pp. 3278-87, (1997) (PubMed).

    Sato, Steeber, Jansen, Tedder: "CD19 expression levels regulate B lymphocyte development: human CD19 restores normal function in mice lacking endogenous CD19." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 158, Issue 10, pp. 4662-9, (1997) (PubMed).

    Krop, de Fougerolles, Hardy, Allison, Schlissel, Fearon: "Self-renewal of B-1 lymphocytes is dependent on CD19." in: European journal of immunology, Vol. 26, Issue 1, pp. 238-42, (1996) (PubMed).

    Krop, Shaffer, Fearon, Schlissel: "The signaling activity of murine CD19 is regulated during cell development." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 157, Issue 1, pp. 48-56, (1996) (PubMed).

    Sato, Ono, Steeber, Pisetsky, Tedder: "CD19 regulates B lymphocyte signaling thresholds critical for the development of B-1 lineage cells and autoimmunity." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 157, Issue 10, pp. 4371-8, (1996) (PubMed).

    Engel, Zhou, Ord, Sato, Koller, Tedder: "Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule." in: Immunity, Vol. 3, Issue 1, pp. 39-50, (1995) (PubMed).

    Rickert, Rajewsky, Roes: "Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice." in: Nature, Vol. 376, Issue 6538, pp. 352-5, (1995) (PubMed).

    Tedder, Zhou, Engel: "The CD19/CD21 signal transduction complex of B lymphocytes." in: Immunology today, Vol. 15, Issue 9, pp. 437-42, (1994) (PubMed).

    Fearon: "The CD19-CR2-TAPA-1 complex, CD45 and signaling by the antigen receptor of B lymphocytes." in: Current opinion in immunology, Vol. 5, Issue 3, pp. 341-8, (1993) (PubMed).

  • Target
    CD19 (CD19 Molecule (CD19))
    Andere Bezeichnung
    CD19 (CD19 Produkte)
    Synonyme
    B4 antikoerper, CVID3 antikoerper, AW495831 antikoerper, CD19 antikoerper, CD19 molecule antikoerper, CD19 antigen antikoerper, CD19 antikoerper, Cd19 antikoerper
    Hintergrund
    The 1D3 antibody reacts with CD19, a B lymphocyte-lineage differentiation antigen. CD19, a 95kDa transmembrance glycoprotein, is a member of the immunoglobulin superfamily and is expressed throughout B-lymphocyte development from the pro-B cell through the mature B-cell stages. Terminally differentiated plasma cells do not express CD19. On the surface of mature B cells, the CD19 molecule associates with CD21 (CR-2) and CD81 (TAPA-1), and this multimolecular complex synergizes with surface immunoglobulin to promote cellular activation. Studies with CD19-deficient mice have suggested that the level of CD19 expression affects the generation and maturation of B cells in the bone marrow and periphery. B-1 lineage B cells, also known as CD5+ B cells, are drastically reduced or absent in CD19-deficient mice. Increased levels of CD19 expression correlate with increased frequencies of peritonal and splenic B-1 cells and reduced numbers of conventional B lymphocytes in the periphery. CD19 participates in B-lymphocyte development, B-cell activation, maturation of memory B cells and regulation of tolerance. CD19 has also been detected on peritoneal mast cells, co-localized with CD20/CD35, and it is proposed to play a role in complement-mediated mast-cell activation. This antibody is routinely tested by flow cytometric analysis.
    Pathways
    Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung
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