TRPV1 Antikörper (Middle Region)

Produktnummer ABIN967211

Produktdetails anti-TRPV1 Antikörper

Target: TRPV1 (Transient Receptor Potential Cation Channel, Subfamily V, Member 1 (TRPV1))

Bindungsspezifität: Middle Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRPV1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Maus, Ratte (Rattus)

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Transient receptor potential cation channel subfamily V member 1 ( TRPV1) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human TRPV1, identical to the related rat and mouse sequences.< br/>Immunogen was affinity purified.

Isotyp: IgG

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide, Thimerosal (Merthiolate)

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: At -20 °C for one year. After reconstitution, at 4 °C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time.

Referenzen für anti-TRPV1 Antikörper (ABIN967211)

Cui, Honore, Zhong, Gauvin, Mikusa, Hernandez, Chandran, Gomtsyan, Brown, Bayburt, Marsh, Bianchi, McDonald, Niforatos, Neelands, Moreland, Decker, Lee, Sullivan, Faltynek: "TRPV1 receptors in the CNS play a key role in broad-spectrum analgesia of TRPV1 antagonists." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 26, Issue 37, pp. 9385-93, (2006) (PubMed).

Birder, Nakamura, Kiss, Nealen, Barrick, Kanai, Wang, Ruiz, De Groat, Apodaca, Watkins, Caterina: "Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1." in: Nature neuroscience, Vol. 5, Issue 9, pp. 856-60, (2002) (PubMed).

Xue, Yu, Trilk, Jong, Schumacher: "The genomic organization of the gene encoding the vanilloid receptor: evidence for multiple splice variants." in: Genomics, Vol. 76, Issue 1-3, pp. 14-20, (2001) (PubMed).

Eisenberg, Gresalfi, Riccio, McLaughlin: "Adsorption of monovalent cations to bilayer membranes containing negative phospholipids." in: Biochemistry, Vol. 18, Issue 23, pp. 5213-23, (1980) (PubMed).

Details zu TRPV1

Target: TRPV1 (Transient Receptor Potential Cation Channel, Subfamily V, Member 1 (TRPV1))

Andere Bezeichnung: Transient receptor potential cation channel subfamily V member 1 (TRPV1) (TRPV1 Produkte)

Synonyme: si:dkey-9e15.2 antikoerper, VR.5'sv antikoerper, Vr1 antikoerper, Vr1l1 antikoerper, VR1 antikoerper, OTRPC1 antikoerper, TRPV1alpha antikoerper, TRPV1beta antikoerper, VR-1 antikoerper, transient receptor potential cation channel, subfamily V, member 1 antikoerper, transient receptor potential cation channel subfamily V member 1 antikoerper, trpv1 antikoerper, Trpv1 antikoerper, TRPV1 antikoerper

Hintergrund: The transient receptor potential cation channel, subfamily V, member 1 (TRPV1), also known as the capsaicin receptor is a protein which in humans is encoded by the TRPV1 gene. TRPV1 (also called Vanilloid receptor type 1) is a ligand-gated nonselective cation channel that is considered to be an important integrator of various pain stimuli such as endogenous lipids, capsaicin, heat, and low pH. In addition to expression in primary afferents, TRPV1 is also expressed in the CNS. Cui M et al. (2006) demonstrate that TRPV1 receptors in the CNS play an important role in pain mediated by central sensitization. And the significant CNS penetration is necessary for a TRPV1 antagonist to produce broad-spectrum analgesia. And TRPV1 also participates in normal bladder function and is essential for normal mechanically evoked purinergic signaling by the urothelium.

Pathways: Dicarboxylic Acid Transport