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SMAD1 Antikörper (C-Term)

SMAD1 Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN967044
  • Target Alle SMAD1 Antikörper anzeigen
    SMAD1 (SMAD, Mothers Against DPP Homolog 1 (SMAD1))
    Bindungsspezifität
    • 23
    • 20
    • 18
    • 15
    • 14
    • 13
    • 11
    • 10
    • 8
    • 6
    • 6
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 207
    • 129
    • 94
    • 9
    • 7
    • 7
    • 6
    • 6
    • 5
    • 5
    • 5
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    Human
    Wirt
    • 207
    • 16
    Kaninchen
    Klonalität
    • 197
    • 27
    Polyklonal
    Konjugat
    • 105
    • 20
    • 13
    • 9
    • 9
    • 9
    • 9
    • 9
    • 9
    • 8
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    Dieser SMAD1 Antikörper ist unkonjugiert
    Applikation
    • 177
    • 91
    • 53
    • 52
    • 44
    • 32
    • 25
    • 19
    • 12
    • 11
    • 6
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Kreuzreaktivität
    Maus, Ratte (Rattus)
    Kreuzreaktivität (Details)
    No cross reactivity with other proteins.
    Produktmerkmale
    Rabbit IgG polyclonal antibody for Mothers against decapentaplegic homolog 1 (SMAD1) detection. Tested with WB in Human, Mouse, Rat.
    Immunogen
    A synthetic peptide corresponding to a sequence at the C-terminal of human Smad 1,2,3,5, identical to the related mouse and rat sequences.< br/>Immunogen was affinity purified.
    Isotyp
    IgG
    Top Product
    Discover our top product SMAD1 Primärantikörper
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    Konservierungsmittel
    Sodium azide, Thimerosal (Merthiolate)
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    At -20 °C for one year. After reconstitution, at 4 °C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time.
  • Zhu, Kavsak, Abdollah, Wrana, Thomsen: "A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation." in: Nature, Vol. 400, Issue 6745, pp. 687-93, (1999) (PubMed).

  • Target
    SMAD1 (SMAD, Mothers Against DPP Homolog 1 (SMAD1))
    Andere Bezeichnung
    Mothers against decapentaplegic homolog 1(MAD homolog 1/Mothers against DPP homolog 1) (SMAD1 Produkte)
    Synonyme
    MLP antikoerper, Xmad1 antikoerper, Xsmad1 antikoerper, bsp1 antikoerper, jv4-1 antikoerper, jv41 antikoerper, madh1 antikoerper, madr1 antikoerper, smad-1 antikoerper, MADH1 antikoerper, fb39h09 antikoerper, wu:fb39h09 antikoerper, wu:fb97e04 antikoerper, 2/23 antikoerper, CG12399 antikoerper, Dmel\\CG12399 antikoerper, E(zen)2 antikoerper, En(vvl) antikoerper, MAD antikoerper, Mat antikoerper, P-Mad antikoerper, P-mad antikoerper, PMad antikoerper, Smad antikoerper, Smad1 antikoerper, apg antikoerper, c28 antikoerper, dMAD antikoerper, dMad antikoerper, l(2)K00237 antikoerper, l(2)k00237 antikoerper, mad antikoerper, p-Mad antikoerper, pMAD antikoerper, pMad antikoerper, pSmad antikoerper, BSP-1 antikoerper, BSP1 antikoerper, JV4-1 antikoerper, JV41 antikoerper, MADR1 antikoerper, AI528653 antikoerper, Madh1 antikoerper, Madr1 antikoerper, Mlp1 antikoerper, MusMLP antikoerper, smad1 antikoerper, xmad antikoerper, SMAD family member 1 antikoerper, Mothers against dpp antikoerper, SMAD family member 1 L homeolog antikoerper, smad1 antikoerper, SMAD1 antikoerper, Mad antikoerper, Smad1 antikoerper, smad1.L antikoerper
    Hintergrund
    SMADs are proteins that modulate the activity of transforming growth factor beta ligands. The SMADs, often in complex with other SMADs/CoSMAD, act as transcription factors that regulate the expression of certain genes. Zhu, H et al concluded that targeted ubiquitination of SMADs may serve to control both embryonic development and a wide variety of cellular responses to TGF-beta signals. R-Smads or receptor regulated Smads are a class of proteins that include SMAD1, SMAD2, SMAD3, SMAD5, and SMAD8. In response to signals by the TGF-beta superfamily of ligands these proteins associate with receptor kinases and are phosphorylated at an SSXS motif at their extreme C-terminus. These proteins then typically bind to the common mediator Smad or co-SMAD SMAD4.
    Pathways
    Stem Cell Maintenance, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
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