PRKDC Antikörper

Produktnummer ABIN966893

Produktdetails anti-PRKDC Antikörper

Target: PRKDC (Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRKDC Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to middle residues of human PRKDC(DNA-dependent protein kinase catalytic subunit)

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: 4 °C

Referenzen für anti-PRKDC Antikörper (ABIN966893)

Ladenburger, Fackelmayer, Hameister, Knippers: "MCM4 and PRKDC, human genes encoding proteins MCM4 and DNA-PKcs, are close neighbours located on chromosome 8q12-->q13." in: Cytogenetics and cell genetics, Vol. 77, Issue 3-4, pp. 268-70, (1997) (PubMed).

Sipley, Menninger, Hartley, Ward, Jackson, Anderson: "Gene for the catalytic subunit of the human DNA-activated protein kinase maps to the site of the XRCC7 gene on chromosome 8." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 16, pp. 7515-9, (1995) (PubMed).

Poltoratsky, Shi, York, Lieber, Carter: "Human DNA-activated protein kinase (DNA-PK) is homologous to phosphatidylinositol kinases." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 155, Issue 10, pp. 4529-33, (1995) (PubMed).

Liu, Ma, Yueh, Lees-Miller, Anderson, Ng: "The carboxyl-terminal transactivation domain of human serum response factor contains DNA-activated protein kinase phosphorylation sites." in: The Journal of biological chemistry, Vol. 268, Issue 28, pp. 21147-54, (1993) (PubMed).

Iijima, Teraoka, Date, Tsukada: "DNA-activated protein kinase in Raji Burkitt's lymphoma cells. Phosphorylation of c-Myc oncoprotein." in: European journal of biochemistry / FEBS, Vol. 206, Issue 2, pp. 595-603, (1992) (PubMed).

Carter, Vancurová, Sun, Lou, DeLeon: "A DNA-activated protein kinase from HeLa cell nuclei." in: Molecular and cellular biology, Vol. 10, Issue 12, pp. 6460-71, (1991) (PubMed).

Lees-Miller, Anderson: "The human double-stranded DNA-activated protein kinase phosphorylates the 90-kDa heat-shock protein, hsp90 alpha at two NH2-terminal threonine residues." in: The Journal of biological chemistry, Vol. 264, Issue 29, pp. 17275-80, (1989) (PubMed).

Details zu PRKDC

Target: PRKDC (Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC))

Andere Bezeichnung: PRKDC (PRKDC Produkte)

Synonyme: DNA-PKcs antikoerper, DNAPK antikoerper, DNPK1 antikoerper, HYRC antikoerper, HYRC1 antikoerper, XRCC7 antikoerper, p350 antikoerper, DNA-PKCS antikoerper, dna-pkcs antikoerper, dnapk antikoerper, dnpk1 antikoerper, hyrc antikoerper, hyrc1 antikoerper, prkdc-A antikoerper, xrcc7 antikoerper, PRKDC antikoerper, AI326420 antikoerper, AU019811 antikoerper, DNAPDcs antikoerper, DOXNPH antikoerper, dxnph antikoerper, p460 antikoerper, scid antikoerper, slip antikoerper, protein kinase, DNA-activated, catalytic polypeptide antikoerper, protein kinase, DNA-activated, catalytic polypeptide L homeolog antikoerper, DNA-dependent protein kinase catalytic subunit antikoerper, protein kinase, DNA activated, catalytic polypeptide antikoerper, PRKDC antikoerper, prkdc.L antikoerper, LOC100633457 antikoerper, Prkdc antikoerper

Hintergrund: PRKDC(DNA-dependent protein kinase catalytic subunit) is a Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. PRKDC must be bound to DNA to express its catalytic properties. PRKDC promotes processing of hairpin DNA structures in V(D)Jrecombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. PRKDC is required to protect and align broken ends of DNA. PRKDC may also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. PRKDC found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. PRKDC also involved in modulation of transcription. PRKDC recognizes the substrate consensus sequence [ST]-Q. PRKDC phosphorylates 'Ser-139' of histone variant H2AX/H2AFX, thereby regulating DNA damage response mechanism. PRKDC phosphorylates DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, SRF, XRCC1, XRCC1, XRCC4, XRCC5, XRCC6, WRN, c-myc/MYC and RFA2. PRKDC can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA. Ability to phosphorylate TP53/p53 in the presence of supercoiled DNA is dependent on C1D.

Pathways: DNA Reparatur, Production of Molecular Mediator of Immune Response