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CCL2 Antikörper

CCL2 Reaktivität: Human WB, ELISA Monoclonal unconjugated
Produktnummer ABIN966545
  • Target Alle CCL2 Antikörper anzeigen
    CCL2 (Chemokine (C-C Motif) Ligand 2 (CCL2))
    Reaktivität
    • 104
    • 66
    • 63
    • 18
    • 18
    • 18
    • 16
    • 9
    • 3
    • 3
    • 2
    • 1
    • 1
    Human
    Wirt
    Bitte anfragen
    Klonalität
    • 135
    • 72
    Monoklonal
    Konjugat
    • 113
    • 39
    • 14
    • 7
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Dieser CCL2 Antikörper ist unkonjugiert
    Applikation
    • 140
    • 74
    • 57
    • 29
    • 28
    • 25
    • 24
    • 18
    • 16
    • 15
    • 14
    • 13
    • 13
    • 13
    • 11
    • 6
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    Spezifität
    Ni-NTA purified recombinant human MCP-1 expressed in E.Coli strain BL21 (DE3).
    Aufreinigung
    Antibodies are purified by protein A affinity chromatography
    Isotyp
    IgG1 kappa
    Top Product
    Discover our top product CCL2 Primärantikörper
  • Applikationshinweise
    Dilution: Western Blot: 1:500-1,000
    ELISA: 1,000-2,000.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Lagerung
    -20 °C
  • Yoshimura, Leonard: "Human monocyte chemoattractant protein-1 (MCP-1)." in: Advances in experimental medicine and biology, Vol. 305, pp. 47-56, (1992) (PubMed).

    Rollins, Morton, Ledbetter, Eddy, Shows: "Assignment of the human small inducible cytokine A2 gene, SCYA2 (encoding JE or MCP-1), to 17q11.2-12: evolutionary relatedness of cytokines clustered at the same locus." in: Genomics, Vol. 10, Issue 2, pp. 489-92, (1991) (PubMed).

    Yoshimura, Yuhki, Moore, Appella, Lerman, Leonard: "Human monocyte chemoattractant protein-1 (MCP-1). Full-length cDNA cloning, expression in mitogen-stimulated blood mononuclear leukocytes, and sequence similarity to mouse competence gene JE." in: FEBS letters, Vol. 244, Issue 2, pp. 487-93, (1989) (PubMed).

  • Target
    CCL2 (Chemokine (C-C Motif) Ligand 2 (CCL2))
    Andere Bezeichnung
    MCP-1 (CCL2 Produkte)
    Synonyme
    GDCF-2 antikoerper, HC11 antikoerper, HSMCR30 antikoerper, MCAF antikoerper, MCP-1 antikoerper, MCP1 antikoerper, SCYA2 antikoerper, SMC-CF antikoerper, AI323594 antikoerper, JE antikoerper, Scya2 antikoerper, Sigje antikoerper, MCP-1A antikoerper, MCP1A antikoerper, C-C motif chemokine ligand 2 antikoerper, chemokine (C-C motif) ligand 2 antikoerper, C-C motif chemokine 2 antikoerper, CCL2 antikoerper, Ccl2 antikoerper, LOC101120093 antikoerper
    Hintergrund
    Monocyte chemoattractant protein-1 (MCP-1) is a member of the chemokine-beta family of cytokines. The protein is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. It may play a inprotant role in the initiation and/or progression of pulmonary hypertension (PH). Blockade of a systemic MCP-1 signal pathway in vivo may prevent PH.
    Pathways
    Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, ER-Nucleus Signaling, Unfolded Protein Response, Phosphorylierungen bei SARS-CoV-2 Infektion
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