IGF1 Antikörper (AA 80-96)

Produktnummer ABIN966342

Produktdetails anti-IGF1 Antikörper

Target: IGF1 (Insulin-Like Growth Factor 1 (IGF1))

Bindungsspezifität: AA 80-96

Reaktivität: Human, Ratte

Wirt: Bitte anfragen

Klonalität: Polyklonal

Konjugat: Dieser IGF1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Immunogen: A synthetic peptide corresponding to a sequence at the middle region of human IGF-1 (80-96 aa), different from the mouse and rat sequence by one amino acid.

Anwendungsinformationen

Applikationshinweise: WB: The detection limit for IGF-1 is approximately 2.5ng/lane under non-reducing and reducing conditions.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: 0.2ml of distilled water will yield a concentration of 500µg/ml.

Buffer: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4

Konservierungsmittel: Thimerosal (Merthiolate), Sodium azide

Lagerung: -20 °C

Referenzen für anti-IGF1 Antikörper (ABIN966342)

Höppener, de Pagter-Holthuizen, Geurts van Kessel, Jansen, Kittur, Antonarakis, Lips, Sussenbach: "The human gene encoding insulin-like growth factor I is located on chromosome 12." in: Human genetics, Vol. 69, Issue 2, pp. 157-60, (1985) (PubMed).

Jansen, van Schaik, Ricker, Bullock, Woods, Gabbay, Nussbaum, Sussenbach, Van den Brande: "Sequence of cDNA encoding human insulin-like growth factor I precursor." in: Nature, Vol. 306, Issue 5943, pp. 609-11, (1984) (PubMed).

Details zu IGF1

Target: IGF1 (Insulin-Like Growth Factor 1 (IGF1))

Andere Bezeichnung: IGF-1 (IGF1 Produkte)

Synonyme: IGF-I antikoerper, IGF1A antikoerper, IGFI antikoerper, C730016P09Rik antikoerper, Igf-1 antikoerper, Igf-I antikoerper, Npt2B antikoerper, IGF-1 antikoerper, IGFIA antikoerper, IGF-IB antikoerper, igf1 antikoerper, IGF-1L antikoerper, IGF-1a antikoerper, IGF1 antikoerper, igf-1 antikoerper, igf1-A antikoerper, igf1.S antikoerper, xigf1 antikoerper, insulin like growth factor 1 antikoerper, insulin-like growth factor 1 antikoerper, insulin-like growth factor I antikoerper, insulin like growth factor 1 L homeolog antikoerper, IGF1 antikoerper, Igf1 antikoerper, LOC100136741 antikoerper, igf1 antikoerper, LOC678666 antikoerper, igf1.L antikoerper, LOC104911603 antikoerper

Hintergrund: Insulin-like growth factor 1 (IGF-1) also known as somatomedin C or mechano growth factor is a protein that in humans is encoded by the IGF1 gene. IGF-1 is a hormone similar in molecular structure to insulin. It plays an important role in childhood growth and continues to have anabolic effects in adults. A synthetic analog of IGF-1, mecasermin is used for the treatment of growth failure. IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges. IGF-1 has a molecular weight of 7649 daltons.Justice et al. (1990) placed the mouse IGF1 gene on chromosome 10.

Pathways: RTK Signalweg, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism, Hormone Activity, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Stem Cell Maintenance, Glycosaminoglycan Metabolic Process, Regulation of Carbohydrate Metabolic Process, Autophagie, Smooth Muscle Cell Migration, Activated T Cell Proliferation, Positive Regulation of fat Cell Differentiation