HSP27 Antikörper

Produktnummer ABIN966308

Produktdetails anti-HSP27 Antikörper

Target: HSP27 (HSPB1) (Heat Shock 27kDa Protein 1 (HSPB1))

Reaktivität: Human, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser HSP27 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human HSP27 expressed in E. Coli.

Klon: 5D7

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western Bloting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
Immunofluorescence: 1/200 - 1/1000.
Flow cytometry: 1/200 - 1/400.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Referenzen für anti-HSP27 Antikörper (ABIN966308)

Langer, Ott, Specht, Becker, Lordick, Burian, Herrmann, Schrattenholz, Cahill, Schwaiger, Hofler, Wester: "Protein expression profiling in esophageal adenocarcinoma patients indicates association of heat-shock protein 27 expression and chemotherapy response." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 14, Issue 24, pp. 8279-87, (2008) (PubMed).

Wu, Liu, Zhang, Huang, Shen, Zhang, Jiang, Luo, Yin: "HSP27 regulates IL-1 stimulated IKK activation through interacting with TRAF6 and affecting its ubiquitination." in: Cellular signalling, Vol. 21, Issue 1, pp. 143-50, (2008) (PubMed).

Details zu HSP27

Target: HSP27 (HSPB1) (Heat Shock 27kDa Protein 1 (HSPB1))

Andere Bezeichnung: HSP27 (HSPB1 Produkte)

Synonyme: CMT2F antikoerper, HMN2B antikoerper, HS.76067 antikoerper, HSP27 antikoerper, HSP28 antikoerper, Hsp25 antikoerper, SRP27 antikoerper, 27kDa antikoerper, Hsp27 antikoerper, cb153 antikoerper, cb660 antikoerper, hsp1 antikoerper, hsp25 antikoerper, hsp27 antikoerper, id:ibd2821 antikoerper, sb:cb660 antikoerper, zgc:103437 antikoerper, HSPB1 antikoerper, cmt2f antikoerper, hs.76067 antikoerper, hsp28 antikoerper, heat shock protein family B (small) member 1 antikoerper, heat shock protein 1 antikoerper, heat shock protein, alpha-crystallin-related, 1 antikoerper, heat shock protein family B (small) member 1 L homeolog antikoerper, HSPB1 antikoerper, Hspb1 antikoerper, hspb1 antikoerper, hspb1.L antikoerper

Hintergrund: The protein encoded by this gene is induced by environmental stress and developmental changes. The encoded protein is involved in stress resistance and actin organization and translocates from the cytoplasm to the nucleus upon stress induction. Defects in this gene are a cause of Charcot-Marie-Tooth disease type 2F (CMT2F) and distal hereditary motor neuropathy (dHMN).
Tissue specificity: Detected in all tissues tested: skeletal muscle, heart, aorta, large intestine, small intestine, stomach, esophagus, bladder, adrenal gland, thyroid, pancreas, testis, adipose tissue, kidney, liver, spleen, cerebral cortex, blood serum and cerebrospinal fluid. Highest levels are found in the heart and in tissues composed of striated and smooth muscle.
Synonyms: CMT2F, HMN2B, HSP27, HSP28, Hsp25, SRP27, HS.76067, DKFZp586P1322, HSPB1

Molekulargewicht: 27kDa

Gen-ID: 3315

Pathways: MAPK Signalweg, Regulation of Actin Filament Polymerization, Signaling Events mediated by VEGFR1 and VEGFR2, Negative Regulation of intrinsic apoptotic Signaling, VEGF Signaling