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USP7 Antikörper

USP7 Reaktivität: Human WB, ELISA Wirt: Maus Monoclonal 5F11 unconjugated
Produktnummer ABIN966249
  • Target Alle USP7 Antikörper anzeigen
    USP7 (Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7))
    Reaktivität
    • 100
    • 35
    • 31
    • 8
    • 6
    • 5
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Wirt
    • 89
    • 9
    • 2
    Maus
    Klonalität
    • 79
    • 21
    Monoklonal
    Konjugat
    • 49
    • 8
    • 6
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser USP7 Antikörper ist unkonjugiert
    Applikation
    • 79
    • 38
    • 30
    • 14
    • 14
    • 13
    • 12
    • 10
    • 9
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA
    Aufreinigung
    Ascitic fluid
    Immunogen
    Purified recombinant fragment of human HAUSP expressed in E. Coli.
    Klon
    5F11
    Isotyp
    IgG1
    Top Product
    Discover our top product USP7 Primärantikörper
  • Applikationshinweise
    Western Bloting: 1/500 - 1/2000.
    ELISA: Propose dilution 1/10000.
    Not yet tested in other applications.
    Determining optimal working dilutions by titration test.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
  • Kotoula, Krikelis, Karavasilis, Koletsa, Eleftheraki, Televantou, Christodoulou, Dimoudis, Korantzis, Pectasides, Syrigos, Kosmidis, Fountzilas: "Expression of DNA repair and replication genes in non-small cell lung cancer (NSCLC): a role for thymidylate synthetase (TYMS)." in: BMC cancer, Vol. 12, Issue 1, pp. 342, (2012) (PubMed).

    Abély: "[Treatment of airway inflammation in cystic fibrosis]." in: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, Vol. 14, Issue 11, pp. 1350-5, (2007) (PubMed).

    MILLER: "Observations on a case of probable bone marrow anthracosis." in: Blood, Vol. 14, pp. 1350-3 (PubMed).

  • Target
    USP7 (Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7))
    Andere Bezeichnung
    HAUSP (USP7 Produkte)
    Synonyme
    CG1490 antikoerper, Dmel\\CG1490 antikoerper, USP7 antikoerper, 2210010O09Rik antikoerper, AA409944 antikoerper, AA617399 antikoerper, AU019296 antikoerper, AW548146 antikoerper, C80752 antikoerper, Hausp antikoerper, HAUSP antikoerper, TEF1 antikoerper, UBP antikoerper, Ubiquitin-specific protease 7 antikoerper, ubiquitin carboxyl-terminal hydrolase 7 antikoerper, ubiquitin specific peptidase 7 antikoerper, Usp7 antikoerper, LOC100201254 antikoerper, USP7 antikoerper
    Hintergrund
    USP7 or HAUSP is a ubiquitin specific protease or a deubiquitylating enzyme that cleaves ubiquitin from its substrates. Since ubiquitylation (polyubiquitination) is most commonly associated with the stability and degradation of cellular proteins, HAUSP acitivity generally stabilizes its substrate proteins. HAUSP is most popularly known as a direct antagonist of Mdm2, the E3 ubiquitin ligase for the tumor suppressor protein, p53.Normally, p53 levels are kept low in part due to Mdm2mediated ubiquitylation and degradation of p53. Interestingly, in response to oncogenic insults, HAUSP can deubiquitinate p53 and protect p53 from Mdm2-mediated degradation, indicating that it may possess a tumor suppressor function for the immediate stabilization of p53 in response to stress. Another important role of HAUSP function involves the oncogenic stabilization of p53. Oncogenes such as Myc and E1A are thought to activate p53 through a p19 alternative reading frame (p19ARF, also called ARF)dependent pathway, although some evidence suggests ARF is not essential in this process. An intriguing possibility is that HAUSP provides an alternative pathway for safeguarding the cell against oncogenic insults.
    Synonyms: TEF1, HAUSP, USP7
    Molekulargewicht
    128kDa
    Gen-ID
    7874
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