FANCD2 Antikörper (Isoform B, ubiquitinated)

Produktnummer ABIN966128

Produktdetails anti-FANCD2 Antikörper

Target: FANCD2 (Fanconi Anemia, Complementation Group D2 (FANCD2))

Bindungsspezifität: Isoform B, ubiquitinated

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FANCD2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktmerkmale: Note: At K561 amino acid residue with the ubiquitin c-terminal 7-mer peptide bound: CLRLRGG

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human FANCD2 (Fanconi anemia complementation group D2 isoform b)

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Referenzen für anti-FANCD2 Antikörper (ABIN966128)

Kweekel, Antonini, Nortier, Punt, Gelderblom, Guchelaar: "Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array." in: British journal of cancer, Vol. 101, Issue 2, pp. 357-62, (2009) (PubMed).

Singh, Bakker, Agarwal, Jansen, Grassman, Godthelp, Ali, Du, Rooimans, Fan, Wahengbam, Steltenpool, Andreassen, Williams, Joenje, de Winter, Meetei: "Impaired FANCD2 monoubiquitination and hypersensitivity to camptothecin uniquely characterize Fanconi anemia complementation group M." in: Blood, Vol. 114, Issue 1, pp. 174-80, (2009) (PubMed).

Kuhnert, Kachnic, Li, Purschke, Gheorghiu, Lee, Held, Willers: "FANCD2-deficient human fibroblasts are hypersensitive to ionising radiation at oxygen concentrations of 0% and 3% but not under normoxic conditions." in: International journal of radiation biology, Vol. 85, Issue 6, pp. 523-31, (2009) (PubMed).

Chan, Palmai-Pallag, Ying, Hickson: "Replication stress induces sister-chromatid bridging at fragile site loci in mitosis." in: Nature cell biology, Vol. 11, Issue 6, pp. 753-60, (2009) (PubMed).

Details zu FANCD2

Target: FANCD2 (Fanconi Anemia, Complementation Group D2 (FANCD2))

Andere Bezeichnung: FANCD2 (FANCD2 Produkte)

Hintergrund: The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity, they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homologydirected DNA repair. Alternative splicing results in two transcript variants encoding different isoforms.

Pathways: DNA Reparatur