ERCC2 Antikörper (C-Term)

Produktnummer ABIN966088

Produktdetails anti-ERCC2 Antikörper

Target: ERCC2 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ERCC2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Aufreinigung: Purified by antigen-specific affinity chromatography.

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human ERCC2(TFIIH basal transcription factor complex helicase subunit)

Anwendungsinformationen

Applikationshinweise: ELISA, Western blotting: 1µg/ml for 2hrs.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: This antibody is stored in PBS, 50% glycerol

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Referenzen für anti-ERCC2 Antikörper (ABIN966088)

Coin, Marinoni, Rodolfo, Fribourg, Pedrini, Egly: "Mutations in the XPD helicase gene result in XP and TTD phenotypes, preventing interaction between XPD and the p44 subunit of TFIIH." in: Nature genetics, Vol. 20, Issue 2, pp. 184-8, (1998) (PubMed).

Details zu ERCC2

Target: ERCC2 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2))

Andere Bezeichnung: ERCC2 (ERCC2 Produkte)

Synonyme: COFS2 antikoerper, EM9 antikoerper, TTD antikoerper, XPD antikoerper, AA407812 antikoerper, AU020867 antikoerper, AW240756 antikoerper, CXPD antikoerper, Ercc-2 antikoerper, MGC89573 antikoerper, CG9433 antikoerper, DhR3 antikoerper, DhXPD antikoerper, DmXPD antikoerper, Dmel\\CG9433 antikoerper, ERCC2 antikoerper, XPD/ERCC2 antikoerper, l(2)SH2 2137 antikoerper, l(2)SH2137 antikoerper, xpd antikoerper, zgc:56365 antikoerper, ERCC excision repair 2, TFIIH core complex helicase subunit antikoerper, excision repair cross-complementing rodent repair deficiency, complementation group 2 antikoerper, excision repair cross-complementation group 2 antikoerper, Xeroderma pigmentosum D antikoerper, ERCC2 antikoerper, Ercc2 antikoerper, ercc2 antikoerper, Xpd antikoerper

Hintergrund: ERCC2(TFIIH basal transcription factor complex helicase subunit) is an ATP-dependent 5'-3' DNA helicase, component of the core-TFIIH basal transcription factor. ERCC2 is involved in nucleotide excision repair (NER) of DNA by opening DNA around the damage, and in RNA transcription by RNA polymerase II by anchoring the CDK-activating kinase (CAK) complex, composed of CDK7, cyclin H and MAT1, to the core-TFIIH complex. ERCC2 might also have a role in aging process and could play a causative role in the generation of skin cancers. One of the six subunits forming the core-TFIIH basal transcription factor. The interaction with p44 results in the stimulation of the 5'-->3' helicase activity. Defects in ERCC2 are the cause of xeroderma pigmentosum complementation group D (XP-D), xeroderma pigmentosum group D combined with Cockayne syndrome (XP-D/CS). Defects in ERCC2 are a cause of trichothiodystrophy (TTD) and COFS syndrome. ERCC2 belongs to the helicase family and RAD3/XPD subfamily.

Pathways: DNA Reparatur