CHEK1 Antikörper (C-Term)

Produktnummer ABIN965880

Produktdetails anti-CHEK1 Antikörper

Target: CHEK1 (Checkpoint Kinase 1 (CHEK1))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CHEK1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Aufreinigung: Purified by antigen-specific affinity chromatography.

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human CHEK1(Serine/threonine-protein kinase Chk1)

Anwendungsinformationen

Applikationshinweise: ELISA, Western blotting: 1µg/ml for 2hrs.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: This antibody is stored in PBS, 50% glycerol

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu CHEK1

Target: CHEK1 (Checkpoint Kinase 1 (CHEK1))

Andere Bezeichnung: CHEK1 (CHEK1 Produkte)

Synonyme: An08g10320 antikoerper, AO090003000441 antikoerper, CHK1 antikoerper, chk1 antikoerper, C85740 antikoerper, Chk1 antikoerper, rad27 antikoerper, id:ibd2720 antikoerper, zgc:56093 antikoerper, CHEK1 antikoerper, checkpoint kinase 1 antikoerper, serine/threonine-protein kinase chk1 antikoerper, serine/threonine-protein kinase Chk1 antikoerper, CAMK/CAMKL/CHK1 protein kinase Chk1 antikoerper, checkpoint kinase 1 S homeolog antikoerper, CHEK1 antikoerper, ANI_1_2436074 antikoerper, AOR_1_768154 antikoerper, PTRG_04183 antikoerper, SJAG_01680 antikoerper, PAAG_04978 antikoerper, MCYG_03290 antikoerper, VDBG_03742 antikoerper, chek1.S antikoerper, Chek1 antikoerper, chek1 antikoerper

Hintergrund: CHEK1(Serine/threonine-protein kinase Chk1) involved in cell cycle arrest when dna damage has occurred or when unligated dna is present. CHEK1 binds to and phosphorylates CDC25A, CDC25B and CDC25C. The phosphorylation of CDC25C creates a binding site for 14-3-3 protein which inhibits CDC25C. This prevents activation of the CDC2-Cyclin B complex and prevents mitotic entry. The CHEK1 phosphorylates CDC25C on serine216. Chk1 plays a primary role in the protection of cells from death induced by replication fork stress, whereas p21 mediates through its role in regulating entry into S phase. Chk1 deficiency resulted in a premature onset of mitosis because of abnormal activation of cyclin B-Cdc2 and led to the activation of caspases 3 and 9 triggered by cytoplasmic release of cytochrome c. It belongs to the Ser/Thr family of protein kinases and NIM1 subfamily.

Pathways: p53 Signalweg, Apoptose, Zellzyklus, DNA Reparatur