CAPN1 Antikörper (AA 312-326)
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- Target Alle CAPN1 Antikörper anzeigen
- CAPN1 (Calpain 1 (CAPN1))
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Bindungsspezifität
- AA 312-326
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Reaktivität
- Human, Maus, Ratte
- Wirt
- Bitte anfragen
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Klonalität
- Polyklonal
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Konjugat
- Dieser CAPN1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Immunogen
- A synthetic peptide corresponding to a sequence at the middle region of human Calpain-1 (312-326 aa), different from the mouse sequence by two amino acids.
- Top Product
- Discover our top product CAPN1 Primärantikörper
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Rekonstitution
- 0.2ml of distilled water will yield a concentration of 500µg/ml.
- Buffer
- Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4
- Konservierungsmittel
- Thimerosal (Merthiolate), Sodium azide
- Lagerung
- -20 °C
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Molecular cloning of the cDNA for the large subunit of the high-Ca2+-requiring form of human Ca2+-activated neutral protease." in: Biochemistry, Vol. 27, Issue 21, pp. 8122-8, (1989) (PubMed).
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Molecular cloning of the cDNA for the large subunit of the high-Ca2+-requiring form of human Ca2+-activated neutral protease." in: Biochemistry, Vol. 27, Issue 21, pp. 8122-8, (1989) (PubMed).
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- Target
- CAPN1 (Calpain 1 (CAPN1))
- Andere Bezeichnung
- Calpain 1 (CAPN1 Produkte)
- Synonyme
- CAPN1 antikoerper, Capa-1 antikoerper, Capa1 antikoerper, mu-calpin antikoerper, Capn1 antikoerper, fj67g01 antikoerper, wu:fj67g01 antikoerper, calpain 1 antikoerper, zgc:55262 antikoerper, CAPN1 antikoerper, Capn1 antikoerper, zgc:55262 antikoerper
- Hintergrund
- Calpain-1 catalytic subunit is a protein that in humans is encoded by the CAPN1 gene. Calpain is an intracellular protease that requires calcium for its catalytic activity. Two isozymes, calpain I (mu-calpain) and calpain II (m-calpain), with different calcium requirements, have been identified. Both are heterodimers composed of L (large, catalytic, 80 kD) and S (small, regulatory, 30 kD) subunits. The isozymes share an identical S subunit, with the differences arising from the L subunits, L1 (CAPN1) and L2. By quantitative RT-PCR, Ueyama et al. (1998) found that expression of calpain-1 and calpain-2 mRNA was significantly increased in muscle biopsy samples derived from 5 men with progressive muscular dystrophy (e.g., DMD, 310200) and 2 men and 3 women with amyotrophic lateral sclerosis (ALS, 105400) compared with controls. Using cDNA clones as probes, Ohno et al. (1989, 1990) assign CANPL1 to chromosome 11.
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