BMPR2 Antikörper

Produktnummer ABIN965686

Produktdetails anti-BMPR2 Antikörper

Target: BMPR2 (Bone Morphogenetic Protein Receptor, Type II (serine/threonine Kinase) (BMPR2))

Reaktivität: Human, Maus, Ratte, Affe

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser BMPR2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human BMPR2 expressed in E. Coli.

Klon: 1F12

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western Bloting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Referenzen für anti-BMPR2 Antikörper (ABIN965686)

Phillips, Poling, Phillips, Stanton, Austin, Cogan, Wheeler, Yu, Newman, Dietz, Loyd: "Synergistic heterozygosity for TGFbeta1 SNPs and BMPR2 mutations modulates the age at diagnosis and penetrance of familial pulmonary arterial hypertension." in: Genetics in medicine : official journal of the American College of Medical Genetics, Vol. 10, Issue 5, pp. 359-65, (2008) (PubMed).

Rosenzweig, Morse, Knowles, Chada, Khan, Roberts, McElroy, Juskiw, Mallory, Rich, Diamond, Barst: "Clinical implications of determining BMPR2 mutation status in a large cohort of children and adults with pulmonary arterial hypertension." in: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, Vol. 27, Issue 6, pp. 668-74, (2008) (PubMed).

Details zu BMPR2

Target: BMPR2 (Bone Morphogenetic Protein Receptor, Type II (serine/threonine Kinase) (BMPR2))

Andere Bezeichnung: BMPR2 (BMPR2 Produkte)

Synonyme: BMPR-II antikoerper, BMPR3 antikoerper, BMR2 antikoerper, BRK-3 antikoerper, PPH1 antikoerper, T-ALK antikoerper, 2610024H22Rik antikoerper, AL117858 antikoerper, AW546137 antikoerper, BB189135 antikoerper, BMP-2 antikoerper, BMPR-2 antikoerper, BMPRII antikoerper, Gm20272 antikoerper, Bmpr-II antikoerper, bmprii antikoerper, bone morphogenetic protein receptor type 2 antikoerper, bone morphogenetic protein receptor, type II b (serine/threonine kinase) antikoerper, bone morphogenetic protein receptor, type II (serine/threonine kinase) antikoerper, BMPR2 antikoerper, bmpr2b antikoerper, Bmpr2 antikoerper

Hintergrund: This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease.
Synonyms: BMR2, PPH1, BMPR3, BRK-3, T-ALK, BMPR-II, FLJ41585, FLJ76945, BMPR2

Molekulargewicht: 115kDa

Gen-ID: 659

Pathways: Growth Factor Binding