ATP2C1 Antikörper

Produktnummer ABIN965621

Produktdetails anti-ATP2C1 Antikörper

Target: ATP2C1 (ATPase, Ca++ Transporting, Type 2C, Member 1 (ATP2C1))

Reaktivität: Human, Affe

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ATP2C1 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of ATP2C1 expressed in E. Coli.

Klon: 4G12

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western Bloting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Referenzen für anti-ATP2C1 Antikörper (ABIN965621)

Yokota, Sawamura: "Hailey-Hailey disease with affective disorder: report of a case with novel ATP2C1 gene mutation." in: Journal of dermatological science, Vol. 43, Issue 2, pp. 150-1, (2006) (PubMed).

Majore, Biolcati, Barboni, Cannistraci, Binni, Crisi, Picardo, Grammatico: "ATP2C1 gene mutation analysis in Italian patients with Hailey-Hailey disease." in: The Journal of investigative dermatology, Vol. 125, Issue 5, pp. 933-5, (2005) (PubMed).

Details zu ATP2C1

Target: ATP2C1 (ATPase, Ca++ Transporting, Type 2C, Member 1 (ATP2C1))

Andere Bezeichnung: ATP2C1 (ATP2C1 Produkte)

Synonyme: ATP2C1 antikoerper, ATP2C1A antikoerper, BCPM antikoerper, HHD antikoerper, PMR1 antikoerper, SPCA1 antikoerper, hSPCA1 antikoerper, Spca1 antikoerper, si:dkey-11p23.6 antikoerper, SPCA antikoerper, 1700121J11Rik antikoerper, AW061228 antikoerper, D930003G21Rik antikoerper, pmr1 antikoerper, ATPase secretory pathway Ca2+ transporting 1 antikoerper, ATPase, Ca++ transporting, type 2C, member 1 antikoerper, ATPase, Ca++-sequestering antikoerper, ATP2C1 antikoerper, atp2c1 antikoerper, Atp2c1 antikoerper

Hintergrund: ATP2C1, also known as PMR1, it belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium. The human homologue, ATP2C1 (also designated SPLA in rat), also regulates the transport of calcium in the Golgi complex and is related to other P-type ATPases family members, such as the sarco(endo)plasmic calcium ATPase (SERCA) and the plasma membrane calcium ATPase (PCMA). ATP2C1 is a transmembrane protein that exists as two splice variants, which vary by 20 amino acids. Defects in ATP2C1 cause Hailey-Hailey disease, which is an autosomal dominant disorder that is characterized by blisters and erosions of the skin. These findings provide further evidence that PMR1 plays a key role in maintaining the integrity of the epidermis by controlling intracellular calcium signaling.
Synonyms: HHD, BCPM, PMR1, SPCA1

Molekulargewicht: 100kDa

Gen-ID: 27032

Pathways: Transition Metal Ion Homeostasis, Ribonucleoside Biosynthetic Process