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Apoa5(bd) Antikörper

Reaktivität: Human ELISA, WB Monoclonal unconjugated
Produktnummer ABIN965572
  • Target
    Apoa5(bd)
    Reaktivität
    Human
    Wirt
    Bitte anfragen
    Klonalität
    • 1
    Monoklonal
    Konjugat
    • 1
    Unkonjugiert
    Applikation
    ELISA, Western Blotting (WB)
    Spezifität
    Ni-NTA purified truncated recombinant human APOA5 expressed in E. Coli strain BL21 (DE3)
    Aufreinigung
    Crude ascites.
    Isotyp
    IgG1
  • Applikationshinweise
    Dilution: Western Blot: 1:500-1,000
    ELISA: Determining optimal working dilutions by titration test.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Lagerung
    -20 °C
  • Target
    Apoa5(bd)
    Hintergrund
    Apolipoprotein A5 (ApoA5) is fast gaining attention as a key regulator of serum triglyceride concentrations. An ApoA5 mouse knock-out model produced an approximately four fold increase in serum triglycerides, whereas a knock-in model with human ApoA5 produced 50-70% lower concentrations of mouse serum triglycerides. In addition, peroxisome proliferator-activated receptor-_ agonists, which are used clinically to lower serum triglyceride concentrations, cause increased ApoA5 mRNA expression. Recently, it was demonstrated that ApoA5 is present in human serum detected by polyclonal antibodies against both the NH2 and COOH termini, although at much lower concentration than other apolipoproteins.
    Gen-ID
    116519
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