ANKH Antikörper (C-Term)

Produktnummer ABIN965553

Produktdetails anti-ANKH Antikörper

Target: ANKH (Ankylosis, Progressive Homolog (Mouse) (ANKH))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ANKH Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Aufreinigung: Purified by antigen-specific affinity chromatography.

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human ANKH(Progressive ankylosis protein homolog)

Anwendungsinformationen

Applikationshinweise: ELISA, Western blotting: 1µg/ml for 2hrs.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: This antibody is stored in PBS, 50% glycerol

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Referenzen für anti-ANKH Antikörper (ABIN965553)

Williams: "Familial calcium pyrophosphate dihydrate deposition disease and the ANKH gene." in: Current opinion in rheumatology, Vol. 15, Issue 3, pp. 326-31, (2003) (PubMed).

Nelson, Clegg, Arnold, Ferguson, Bonham, White, Hood, Lin: "The program of androgen-responsive genes in neoplastic prostate epithelium." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 18, pp. 11890-5, (2002) (PubMed).

Williams, Zhang, Timms, Bonavita, Caeiro, Broxholme, Cuthbertson, Jones, Marchegiani, Reginato, Russell, Wordsworth, Carr, Brown: "Autosomal dominant familial calcium pyrophosphate dihydrate deposition disease is caused by mutation in the transmembrane protein ANKH." in: American journal of human genetics, Vol. 71, Issue 4, pp. 985-91, (2002) (PubMed).

Details zu ANKH

Target: ANKH (Ankylosis, Progressive Homolog (Mouse) (ANKH))

Andere Bezeichnung: ANKH (ANKH Produkte)

Synonyme: ANK antikoerper, CCAL2 antikoerper, CMDJ antikoerper, CPPDD antikoerper, HANK antikoerper, MANK antikoerper, Ank antikoerper, Ankh antikoerper, D15Ertd221e antikoerper, ank antikoerper, mKIAA1581 antikoerper, ankh antikoerper, wu:fc08d03 antikoerper, wu:fj64g09 antikoerper, zgc:110290 antikoerper, ANKH inorganic pyrophosphate transport regulator antikoerper, progressive ankylosis antikoerper, ANKH inorganic pyrophosphate transport regulator b antikoerper, ANKH inorganic pyrophosphate transport regulator S homeolog antikoerper, ANKH inorganic pyrophosphate transport regulator a antikoerper, ANKH antikoerper, Ankh antikoerper, Ank antikoerper, ankhb antikoerper, ankh.S antikoerper, ankha antikoerper

Hintergrund: The ANKH (progressive ankylosis protein homolog) is a multipass transmembrane protein that is expressed in joints and other tissues and controls pyrophosphate levels in cultured cells. The ANKHOR and ANKH-TR are novel genetic markers that are significantly associated with ankylosing spondylitis. Mutation at the mouse `progressive ankylosis' (ank) locus causes a generalized, progressive form of arthritis accompanied by mineral deposition, formation of bony outgrowths, and joint destruction. The human homolog is virtually identical to the mouse protein and ANKH-mediated control of pyrophosphate levels has been suggested as a possible mechanism regulating tissue calcification and susceptibility to arthritis in higher animals.