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WWTR1 Antikörper (C-Term)

WWTR1 Reaktivität: Human WB, EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN955592
  • Target Alle WWTR1 Antikörper anzeigen
    WWTR1 (WW Domain Containing Transcription Regulator 1 (WWTR1))
    Bindungsspezifität
    • 10
    • 6
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 369-398, C-Term
    Reaktivität
    • 37
    • 16
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 33
    • 4
    Kaninchen
    Klonalität
    • 33
    • 4
    Polyklonal
    Konjugat
    • 22
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser WWTR1 Antikörper ist unkonjugiert
    Applikation
    • 30
    • 16
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Spezifität
    This antibody detects WWTR1 / TAZ (C-term).
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human
    Aufreinigung
    Protein A column followed by peptide affinity purification
    Immunogen
    KLH conjugated synthetic peptide between 369-398 amino acids from the C-terminal region of human WWTR1.
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product WWTR1 Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.25 mg/mL
    Buffer
    PBS with 0.09 % (W/V) sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.
  • Target
    WWTR1 (WW Domain Containing Transcription Regulator 1 (WWTR1))
    Andere Bezeichnung
    WWTR1 / TAZ (WWTR1 Produkte)
    Synonyme
    WWTR1 antikoerper, TAZ antikoerper, 2310058J06Rik antikoerper, 2610021I22Rik antikoerper, C78399 antikoerper, Taz antikoerper, WW domain containing transcription regulator 1 L homeolog antikoerper, WW domain containing transcription regulator 1 antikoerper, wwtr1.L antikoerper, wwtr1 antikoerper, WWTR1 antikoerper, Wwtr1 antikoerper
    Hintergrund
    Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.Synonyms: Transcriptional coactivator with PDZ-binding motif, WW domain-containing transcription regulator protein 1
    Gen-ID
    25937
    NCBI Accession
    NP_001161750
    Pathways
    Regulation of Lipid Metabolism by PPARalpha
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