WWOX Antikörper (C-Term)

Produktnummer ABIN955590

Produktdetails anti-WWOX Antikörper

Target: WWOX (WW Domain Containing Oxidoreductase (WWOX))

Bindungsspezifität: AA 368-396, C-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser WWOX Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Spezifität: This antibody detects WWOX / FOR (C-term).

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse

Aufreinigung: Protein A column followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 368-396 amino acids from the C-terminal region of human WWOX

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.

Details zu WWOX

Target: WWOX (WW Domain Containing Oxidoreductase (WWOX))

Andere Bezeichnung: WWOX / FOR (WWOX Produkte)

Hintergrund: WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90 % identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates transcript variants that encode different isoforms.Synonyms: FOR I, FOR II, FOR III, FOR IV, FOR1, FOR2, FOR3, Fragile site FRA16D oxidoreductase, WOX1, WOX2, WOX3, WW domain-containing oxidoreductase, WWOXdelta5-8, WWOXdelta6-8, WWOXv1, WWOXv2, WWOXv3, WWOXv4, WWOXv8

Gen-ID: 51741

NCBI Accession: NP_057457