TMEM173 Antikörper (Transmembrane Protein 173) (C-Term)

Details for Product anti-TMEM173 Antibody No. ABIN955254, Anbieter: Anmelden zum Anzeigen
Antigen
  • ERIS
  • MITA
  • MPYS
  • NET23
  • STING
  • 2610307O08Rik
  • Mita
  • RGD1562552
  • transmembrane protein 173
  • TMEM173
  • Tmem173
Alternativen
anti-Maus TMEM173 Antikörper für ELISA
Epitop
C-Term, AA 318-348
18
13
10
5
5
5
4
2
2
2
2
2
1
1
1
Reaktivität
Human, Maus
135
39
29
2
2
1
1
1
1
1
1
Wirt
Kaninchen
96
46
Klonalität
Polyklonal
Konjugat
Dieser TMEM173 Antikörper ist unkonjugiert
6
6
3
3
3
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
Applikation
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Western Blotting (WB)
97
51
47
41
20
15
13
13
10
7
4
3
1
Optionen
Hersteller
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Immunogen KLH conjugated synthetic peptide between 318~348 amino acids from the C-terminal region of human TM173
Isotyp Ig
Spezifität This antibody detects TMEM173 / STING (C-term).
Kreuzreaktivität (Details) Species reactivity (tested):Human, mouse
Reinigung Protein A column followed by peptide affinity purification
Andere Bezeichnung TMEM173 / STING (TMEM173 Antibody Abstract)
Hintergrund Acts as a facilitator of innate immune signaling. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon (IFN-alpha and IFN-beta) and exert a potent anti-viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.Synonyms: MITA, Mediator of IRF3 activation, Stimulator of interferon genes protein, Transmembrane protein 173
Gen-ID 340061
NCBI Accession NP_938023
Pathways Activation of Innate immune Response
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.
Bilder des Herstellers
Flow Cytometry (FACS) image for anti-TMEM173 Antikörper (Transmembrane Protein 173) (C-Term) (ABIN955254) TM173 Antibody (C-term) flow cytometric analysis of Hela cells (right histogram) comp...
Western Blotting (WB) image for anti-TMEM173 Antikörper (Transmembrane Protein 173) (C-Term) (ABIN955254) Western blot analysis of TM173 Antibody (C-term) in mouse spleen tissue lysates (35 µ...
Allgemeine Veröffentlichungen Sun, Li, Chen, Chen, You, Zhou, Zhou, Zhai, Chen, Jiang: "ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 21, pp. 8653-8, 2009 (PubMed).

Zhong, Zhang, Lei, Li, Mao, Yang, Wang, Zhang, Shu: "The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA." in: Immunity, Vol. 30, Issue 3, pp. 397-407, 2009 (PubMed).