SAR1B Antikörper (Middle Region)

Produktnummer ABIN954670

Produktdetails anti-SAR1B Antikörper

Target: SAR1B (SAR1 Homolog B (SAR1B))

Bindungsspezifität: AA 96-124, Middle Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SAR1B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Spezifität: Recognizes SAR1B (Center).

Aufreinigung: Protein A column followed by peptide Affinity purification

Immunogen: KLH conjugated synthetic peptide between 96-124 amino acids from the Central region of Human SAR1B Genename: SAR1B

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) Sodium Azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu SAR1B

Target: SAR1B (SAR1 Homolog B (SAR1B))

Andere Bezeichnung: SAR1B (SAR1B Produkte)

Synonyme: SAR1 antikoerper, SAR1B antikoerper, SARA2 antikoerper, 2310075M17Rik antikoerper, 2900019I22Rik antikoerper, CMRD antikoerper, Sara1b antikoerper, Sara2 antikoerper, Sarb antikoerper, cmrd antikoerper, gtbpb antikoerper, sar1a antikoerper, sara2 antikoerper, SARA1B antikoerper, ANDD antikoerper, GTBPB antikoerper, zgc:73204 antikoerper, secretion associated Ras related GTPase 1B antikoerper, hypothetical protein antikoerper, SAR1 homolog B (S. cerevisiae) antikoerper, secretion associated, Ras related GTPase 1B L homeolog antikoerper, secretion associated, Ras related GTPase 1B antikoerper, SAR1B antikoerper, Sar1B antikoerper, sar1b antikoerper, Sar1b antikoerper, sar1b.L antikoerper

Hintergrund: SAR1B belongs to the small GTPase superfamily, SAR1 family. It is involved in transport from the endoplasmic reticulum to the Golgi apparatus and is activated by the guanine nucleotide exchange factor PREB. SAR1B is involved in the selection of the protein cargo and the assembly of the COPII coat complex. Defects in SAR1B are the cause of chylomicron retention disease (CMRD). CMRD is an autosomal recessive disorder of severe fat malabsorption associated with failure to thrive in infancy. The conditions are characterized by deficiency of fat-soluble vitamins, low blood cholesterol levels, and a selective absence of chylomicrons from blood. Affected individuals accumulate chylomicron-like particles in membrane-bound compartments of enterocytes, which contain large cytosolic lipid droplets. Cellular localization: Endoplasmic reticulum membrane, Peripheral membrane protein. Golgi apparatus, Golgi stack membrane, Peripheral membrane protein. Associated with the endoplasmic reticulum and Golgi stacks, in particular in the juxta-nuclear Golgi region.Synonyms: GTBPB, GTP-binding protein SAR1b, SAR1B, SARA2, SARB

Gen-ID: 51128

NCBI Accession: NP_001028675

Pathways: Lipid Metabolism