S100A8 Antikörper (S100 Calcium Binding Protein A8) (FITC)

Details for Product anti-S100A8 Antibody No. ABIN954653, Anbieter: Anmelden zum Anzeigen
Antigen
  • EWWD
  • MRP8
  • WW
  • 60B8AG
  • CAGA
  • CFAG
  • CGLA
  • CP-10
  • L1Ag
  • MA387
  • MIF
  • NIF
  • P8
  • Mrp8
  • S100A8
  • 60B8Ag
  • AI323541
  • B8Ag
  • CFAg
  • Caga
  • p8
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 11
  • S100 calcium binding protein A8
  • S100 calcium binding protein A8 (calgranulin A)
  • ABCC11
  • S100A8
  • S100a8
Alternativen
anti-Human S100A8 Antikörper für Cytometry by Time of Flight
Reaktivität
Human
172
70
46
10
9
5
4
4
3
2
2
1
Wirt
Maus
113
84
29
22
4
1
Klonalität (Klon)
Monoklonal ()
Konjugat
Dieser S100A8 Antikörper ist konjugiert mit FITC
26
21
11
4
4
4
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
Applikation
Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
187
114
63
62
46
26
23
15
9
8
7
7
7
1
1
1
Optionen
Hersteller
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Immunogen Purified granulocyte antigen of Human origin.
Klon CF-145
Isotyp IgG2b
Spezifität This antibody detects Calgranulin A (S100A8).
Kreuzreaktivität (Details) Species reactivity (tested):Human.
Reinigung Protein G Chromatography of Ascitic fluid.
Andere Bezeichnung S100A8 / Calgranulin-A / MRP8 (S100A8 Antibody Abstract)
Hintergrund Calgranulin A, also known as MRP-8 and S100A8 is a member of the S100 family of proteins containing 2 EF hand (alpha helix, turn, alpha helix structure) calcium binding motifs. S100 proteins are localized in the cytoplasm and /or nucleus of a wide range of cells and are involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. MRP-8 (S100A8) forms a heterodimeric complex with Calgranulin B, (MRP-14, S100A9) in the cytosol of monocyte and neutrophil cell types circulating in peripheral blood. Calgranulin A is found in elevated levels in the serum of cystic fibrosis cases and is also expressed in the skin of patients with psoriasis, eczematous dermatitis and squamous cell carcinoma.Synonyms: CAGA, CFAG, Calprotectin L1L subunit, Cystic fibrosis antigen, Leukocyte L1 complex light chain, MRP-8, Migration inhibitory factor-related protein 8, S100 calcium-binding protein A8, S100-A8, Urinary stone protein band A
Gen-ID 6279
NCBI Accession NP_002955
UniProt P05109
Forschungsgebiet Cell Cycle
Pathways Transition Metal Ion Homeostasis, Positive Regulation of Endopeptidase Activity
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 0.1 mg/mL
Buffer PBS containing 0.02 % Sodium Azide as preservative and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/mL.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Bilder des Herstellers
Immunohistochemistry (IHC) image for anti-S100A8 Antikörper (S100 Calcium Binding Protein A8)  (FITC) (ABIN954653) anti-S100 Calcium Binding Protein A8 (S100A8) antibody (FITC)
Flow Cytometry (FACS) image for anti-S100A8 Antikörper (S100 Calcium Binding Protein A8)  (FITC) (ABIN954653) anti-S100 Calcium Binding Protein A8 (S100A8) antibody (FITC) (Image 2)
Allgemeine Veröffentlichungen Thacher, Nagpal, Klein, Arefieg, Krasinski, DiSepio, Agarwal, Johnson, Eckert, Chandraratna: "Cell type and gene-specific activity of the retinoid inverse agonist AGN 193109: divergent effects from agonist at retinoic acid receptor gamma in human keratinocytes." in: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, Vol. 10, Issue 4, pp. 255-62, 1999 (PubMed).

Nagpal, Thacher, Patel, Friant, Malhotra, Shafer, Krasinski, Asano, Teng, Duvic, Chandraratna: "Negative regulation of two hyperproliferative keratinocyte differentiation markers by a retinoic acid receptor-specific retinoid: insight into the mechanism of retinoid action in psoriasis." in: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, Vol. 7, Issue 12, pp. 1783-91, 1997 (PubMed).

Klein, Pino, Johnson, Davies, Nagpal, Thacher, Krasinski, Chandraratna: "Identification and functional separation of retinoic acid receptor neutral antagonists and inverse agonists." in: The Journal of biological chemistry, Vol. 271, Issue 37, pp. 22692-6, 1996 (PubMed).