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S100A8 Antikörper (S100 Calcium Binding Protein A8) (FITC)

Details für Produkt anti-S100A8 Antikörper Nr. ABIN954653, Anbieter: Anmelden zum Anzeigen
Antigen
  • 60B8AG
  • 60B8Ag
  • AI323541
  • B8Ag
  • Caga
  • CAGA
  • CFAG
  • CFAg
  • CGLA
  • CP-10
  • L1Ag
  • MA387
  • MIF
  • MRP8
  • Mrp8
  • NIF
  • P8
  • p8
  • S100A8
Reaktivität
Human
133
61
36
8
4
1
Wirt
Maus
94
76
20
15
4
1
Klonalität (Klon)
Monoklonal ()
Konjugat
Dieser S100A8 Antikörper ist konjugiert mit FITC
25
20
10
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Applikation
Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
147
103
57
41
32
18
14
13
12
8
5
1
1
1
1
1
Hersteller
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Immunogen Purified granulocyte antigen of Human origin.
Klon CF-145
Isotyp IgG2b
Spezifität This antibody detects Calgranulin A (S100A8).
Kreuzreaktivität (Details) Species reactivity (tested):Human.
Reinigung Protein G Chromatography of Ascitic fluid.
Andere Bezeichnung S100A8 / Calgranulin-A / MRP8 (S100A8 Antibody Abstract)
Hintergrund Calgranulin A, also known as MRP-8 and S100A8 is a member of the S100 family of proteins containing 2 EF hand (alpha helix, turn, alpha helix structure) calcium binding motifs. S100 proteins are localized in the cytoplasm and /or nucleus of a wide range of cells and are involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. MRP-8 (S100A8) forms a heterodimeric complex with Calgranulin B, (MRP-14, S100A9) in the cytosol of monocyte and neutrophil cell types circulating in peripheral blood. Calgranulin A is found in elevated levels in the serum of cystic fibrosis cases and is also expressed in the skin of patients with psoriasis, eczematous dermatitis and squamous cell carcinoma.Synonyms: CAGA, CFAG, Calprotectin L1L subunit, Cystic fibrosis antigen, Leukocyte L1 complex light chain, MRP-8, Migration inhibitory factor-related protein 8, S100 calcium-binding protein A8, S100-A8, Urinary stone protein band A
Gen-ID 6279
NCBI Accession NP_002955
UniProt P05109
Forschungsgebiet Cell Cycle
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 0.1 mg/mL
Buffer PBS containing 0.02 % Sodium Azide as preservative and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/mL.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Bilder des Herstellers
Immunohistochemistry (IHC) image for anti-S100A8 Antikörper (S100 Calcium Binding Protein A8)  (FITC) (ABIN954653) anti-S100 Calcium Binding Protein A8 (S100A8) antibody (FITC)
Flow Cytometry (FACS) image for anti-S100A8 Antikörper (S100 Calcium Binding Protein A8)  (FITC) (ABIN954653) anti-S100 Calcium Binding Protein A8 (S100A8) antibody (FITC) (Image 2)
Allgemeine Veröffentlichungen Thacher, Nagpal, Klein, Arefieg, Krasinski, DiSepio, Agarwal, Johnson, Eckert, Chandraratna: "Cell type and gene-specific activity of the retinoid inverse agonist AGN 193109: divergent effects from agonist at retinoic acid receptor gamma in human keratinocytes." in: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, Vol. 10, Issue 4, pp. 255-62, 1999 (PubMed).

Nagpal, Thacher, Patel, Friant, Malhotra, Shafer, Krasinski, Asano, Teng, Duvic, Chandraratna: "Negative regulation of two hyperproliferative keratinocyte differentiation markers by a retinoic acid receptor-specific retinoid: insight into the mechanism of retinoid action in psoriasis." in: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, Vol. 7, Issue 12, pp. 1783-91, 1997 (PubMed).

Klein, Pino, Johnson, Davies, Nagpal, Thacher, Krasinski, Chandraratna: "Identification and functional separation of retinoic acid receptor neutral antagonists and inverse agonists." in: The Journal of biological chemistry, Vol. 271, Issue 37, pp. 22692-6, 1996 (PubMed).