IA-2 antikoerper, IA-2/PTP antikoerper, IA2 antikoerper, ICA512 antikoerper, R-PTP-N antikoerper, mIA-A antikoerper, mKIAA4064 antikoerper, Ia-2 antikoerper, fc43c04 antikoerper, ptprn antikoerper, wu:fc43c04 antikoerper, ia-2 antikoerper, ia2 antikoerper, ica512 antikoerper, r-ptp-n antikoerper, protein tyrosine phosphatase, receptor type N antikoerper, protein tyrosine phosphatase, receptor type, N antikoerper, protein tyrosine phosphatase, receptor type, Na antikoerper, protein tyrosine phosphatase, receptor type N L homeolog antikoerper, PTPRN antikoerper, Ptprn antikoerper, ptprna antikoerper, ptprn.L antikoerper
Hintergrund
IA-2, a R8 receptor protein tyrosine phosphatase, is one of the major autoantigens in type 1 diabetes. Autoantibodies against IA-2 have been detected in large numbers newly diagnosed patients with type 1 diabetes and appear to identify a subgroup of prediabetic subjects who rapidly progress to type 1 diabetes, however, IA-2 polymorphisms do not appear to be associated with type 1 diabetes. Three alternative spliced variants of IA-2 have been documented and alternative splicing of IA-2 gene has been suggested to be a permissive genetic mechanism for autoimmunity against the IA-2 type 1 diabetes autoantigen.Synonyms: ICA3, ICA512, Islet cell antigen 512, PTP IA-2, R-PTP-N, Receptor-type tyrosine-protein phosphatase-like N