MYSM1 Antikörper (N-Term)

Produktnummer ABIN953592

Produktdetails anti-MYSM1 Antikörper

Target: MYSM1 (Myb-Like, SWIRM and MPN Domains 1 (MYSM1))

Bindungsspezifität: AA 118-147, N-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MYSM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Spezifität: This antibody recognizes MYSM1 at N-term.

Kreuzreaktivität (Details): Species reactivity (tested):Human, Mouse

Aufreinigung: Purified through a Protein A column followed by peptide affinity purification

Immunogen: Synthetic peptide - KLH conjugated - corresponding to the N-terminal region (between 118-147aa) of human MYSM1

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) Sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Referenzen für anti-MYSM1 Antikörper (ABIN953592)

Dephoure, Zhou, Villén, Beausoleil, Bakalarski, Elledge, Gygi: "A quantitative atlas of mitotic phosphorylation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 31, pp. 10762-7, (2008) (PubMed).

Details zu MYSM1

Target: MYSM1 (Myb-Like, SWIRM and MPN Domains 1 (MYSM1))

Andere Bezeichnung: MYSM1 (MYSM1 Produkte)

Synonyme: 2A-DUB antikoerper, 2ADUB antikoerper, RP4-592A1.1 antikoerper, C130067A03Rik antikoerper, C530050H10Rik antikoerper, RGD1311787 antikoerper, 2adub antikoerper, Myb like, SWIRM and MPN domains 1 antikoerper, myb-like, SWIRM and MPN domains 1 antikoerper, Myb like, SWIRM and MPN domains 1 L homeolog antikoerper, MYSM1 antikoerper, Mysm1 antikoerper, mysm1.L antikoerper

Hintergrund: Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation.Synonyms: Histone H2A deubiquitinase MYSM1, KIAA1915, Myb-like SWIRM and MPN domain-containing protein 1

Gen-ID: 114803

NCBI Accession: NP_001078956

Pathways: Chromatin Binding