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CD27 Antikörper (CD27 Molecule) (FITC)

Details für Produkt anti-CD27 Antikörper Nr. ABIN951255, Anbieter: Anmelden zum Anzeigen
Antigen
  • TNFRSF7
  • S152
  • Tnfrsf7
  • Tp55
  • S152. LPFS2
  • T14
  • CD27 molecule
  • CD27 antigen
  • CD27
  • Cd27
Alternativen
anti-Maus CD27 Antikörper für ELISA
Reaktivität
Maus
443
170
66
8
8
8
3
3
1
1
1
1
Wirt
Hamster
279
94
60
41
38
6
Klonalität (Klon)
Monoklonal ()
Konjugat
Dieser CD27 Antikörper ist konjugiert mit FITC
51
49
31
23
14
13
13
13
11
10
10
8
7
7
7
7
6
6
6
6
5
5
5
5
5
4
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Applikation
Functional Studies (Func), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
422
79
68
61
57
46
45
25
18
15
13
8
5
4
3
2
2
2
2
1
1
1
1
Optionen
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Bilder

Immunogen MCD27 tag expressing clones AR0524 and AR0530 from Armenian Hamster spleen.
Klon LG-3A10
Isotyp IgG1
Spezifität Recognizes Mouse CD27 receptor.
Kreuzreaktivität (Details) Species reactivity (tested):Mouse.
Reinigung Protein G Chromatography.
Andere Bezeichnung CD27 (CD27 Antibody Abstract)
Hintergrund CD27 is part of the Tumor Necrosis Factor (TNF) family of receptors and is lymphocyte specific. Murine CD27 is expressed on the great majority of both αβ and γδ T lymphocytes, on a small population of peripheral B cells and on a very small subset of B220+ cells in the bone marrow. Murine CD27 is found on all thymocytes except a subset of CD4-CD8- precursors. There are two known basic functions of CD27 signaling. First, the binding of CD27 to CD70, a protein which is also expressed in T and B cells, provides costimulatory signals in lymphocyte proliferation and immunoglobulin production. Second, the association of CD27 with intracellular Siva, a proapoptotic protein, results in the induction of apoptotic events.Synonyms: CD27L receptor, T-cell activation antigen CD27, T14, TNFRSF7, Tumor necrosis factor receptor superfamily member 7
Gen-ID 21940
NCBI Accession NP_001028298
UniProt P41272
Forschungsgebiet Immunology, Adaptive Immunity, Hematopoietic Progenitors, Cytokines, Innate Immunity, CD Antigens, Surface Receptors of Immune Cells
Pathways Production of Molecular Mediator of Immune Response
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 0.1 mg/mL
Buffer PBS, 0.02 % Sodium Azide, EIA grade BSA to bring total protein concentration to 4-5 mg/mL
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. This product is photosensitive and should be protected from light.
Bilder des Herstellers
Flow Cytometry (FACS) image for anti-CD27 Antikörper (CD27 Molecule)  (FITC) (ABIN951255) anti-CD27 Molecule (CD27) antibody (FITC)
Allgemeine Veröffentlichungen Henke, Launhardt, Klement, Stelzner, Zell, Munder: "Apoptosis in coxsackievirus B3-caused diseases: interaction between the capsid protein VP2 and the proapoptotic protein siva." in: Journal of virology, Vol. 74, Issue 9, pp. 4284-90, 2000 (PubMed).

Gravestein, Nieland, Kruisbeek, Borst: "Novel mAbs reveal potent co-stimulatory activity of murine CD27." in: International immunology, Vol. 7, Issue 4, pp. 551-7, 1995 (PubMed).