CARD16 Antikörper (N-Term)

Produktnummer ABIN951040

Produktdetails anti-CARD16 Antikörper

Target: CARD16 (Caspase Recruitment Domain Family, Member 16 (CARD16))

Bindungsspezifität: AA 44-73, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CARD16 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Spezifität: This antibody reacts to COP1.

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: Affinity chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 44-73 amino acids from the N-terminal region of human COP1

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS, 0.09 % (W/V) sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu CARD16

Target: CARD16 (Caspase Recruitment Domain Family, Member 16 (CARD16))

Andere Bezeichnung: CARD16 / COP1 (CARD16 Produkte)

Synonyme: COP antikoerper, COP1 antikoerper, PSEUDO-ICE antikoerper, caspase recruitment domain family member 16 antikoerper, CARD16 antikoerper

Hintergrund: Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2.Synonyms: CARD only domain-containing protein 1, Caspase recruitment domain-containing protein 16, Caspase-1 inhibitor COP, PSEUDO-ICE, Pseudo interleukin-1 beta converting enzyme

Molekulargewicht: 22625 Da

Gen-ID: 114769

NCBI Accession: NP_001017534