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Actl7b Antikörper (Actin-Like 7b) (N-Term)

Details für Produkt anti-Actl7b Antikörper Nr. ABIN950264, Anbieter: Anmelden zum Anzeigen
Antigen
  • ACTL7B
  • Tact1
Epitop
N-Term, AA 68-97
25
16
15
15
11
7
7
4
4
2
2
2
2
1
Reaktivität
Human
59
37
12
2
Wirt
Kaninchen
54
31
9
Klonalität
Polyklonal
Konjugat
Dieser Actl7b Antikörper ist unkonjugiert
6
6
6
6
6
6
Applikation
Enzyme Immunoassay (EIA), Western Blotting (WB)
86
57
7
3
Hersteller
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Immunogen KLH conjugated synthetic peptide between 68-97 amino acids from the N-terminal region of human ACTL7B
Isotyp Ig
Spezifität This antibody reacts to ACTL7B.
Kreuzreaktivität (Details) Species reactivity (tested):Human.
Reinigung Affinity chromatography on Protein A
Andere Bezeichnung ACTL7B (Actl7b Antibody Abstract)
Hintergrund The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene (ACTL7B), and related gene, ACTL7A, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7B gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. Unlike ACTL7A, the ACTL7B gene is expressed predominantly in the testis, however, its exact function is not known.Synonyms: Actin-like protein 7B, Actin-like-7-beta
Gen-ID 10880
NCBI Accession NP_006677
Forschungsgebiet Signaling, Cytoskeleton, Microfilaments
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) sodium azide as preservative
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Bilder des Herstellers
Western Blotting (WB) image for anti-Actl7b Antikörper (Actin-Like 7b) (N-Term) (ABIN950264) ACTL7B Antibody (N-term) western blot analysis in NCI-H292 cell line lysates (35µg/la...
Allgemeine Veröffentlichungen Humphray, Oliver, Hunt, Plumb, Loveland, Howe, Andrews, Searle, Hunt, Scott, Jones, Ainscough, Almeida, Ambrose, Ashwell, Babbage, Babbage, Bagguley, Bailey, Banerjee, Barker, Barlow, Bates, Beasley et al.: "DNA sequence and analysis of human chromosome 9. ..." in: Nature, Vol. 429, Issue 6990, pp. 369-74, 2004

Hisano, Ohta, Nishimune, Nozaki: "Methylation of CpG dinucleotides in the open reading frame of a testicular germ cell-specific intronless gene, Tact1/Actl7b, represses its expression in somatic cells." in: Nucleic acids research, Vol. 31, Issue 16, pp. 4797-804, 2003

Klionsky, Ohsumi: "Vacuolar import of proteins and organelles from the cytoplasm." in: Annual review of cell and developmental biology, Vol. 15, pp. 1-32, 2000

Chadwick, Mull, Helbling, Gill, Leyne, Robbins, Pinkett, Makalowska, Maayan, Blumenfeld, Axelrod, Brownstein, Gusella, Slaugenhaupt: "Cloning, mapping, and expression of two novel actin genes, actin-like-7A (ACTL7A) and actin-like-7B (ACTL7B), from the familial dysautonomia candidate region on 9q31." in: Genomics, Vol. 58, Issue 3, pp. 302-9, 1999