Amyloid Antikörper

Antigen: Amyloid

Klonalität: Monoklonal (BAM-10)

Wirt: Maus

Reaktivität: Human

Applikation: Immunhistochemie (Paraffinschnitte) (IHC (p))

Produktnummer: ABIN95019

Produktbeschreibung

Immunogen: A synthetic beta-amyloid peptide (1-40) conjugated to KLH.

Format: Ascites (prediluted)

Isotyp: IgG1  (Passende Sekundärantikörper)

Klon: BAM-10

Spezifität: This antibody reacts with beta-amyloid protein. This antibody stains Amyloid plaques within the cortex, and Amyloid deposits in blood vessels. Beta-amyloid deposits are also detected in Lewy body dementia, Down's syndrome, amyloidosis and in Gram-Parkinson dementia complex. The presence to a large number of neuritic plaques (senile) and neurofibrillary tangles in the cerebral cortex is used a pathological marker for a disease state and presents the major criterion for the diagnosis of Alzheimer's disease at autopsy.

Anwendungen

Applikationshinweise: Titer/Working Dilution: This antibody may be diluted to a titer of 1:50-1:100 in an ABC method. However, depending on the staining conditions employed, we suggest that final dilution should be determined by the user. Staining Protocol: We suggest an incubation period of 30 minutes at room temperature. However, depending upon the fixation conditions and the staining system employed, optimal incubation should be determined by the user. Suitable for formalin/paraffin tissues. Positive Control: Brain. Cellular localization: Cytoplasmic

Konzentration: 100ug/ml approximately

Buffer: This antibody is supplied as diluted ascites containing sodium azide as preservative.

Lagerung: Store the antibody at 2-8o c. Do not use it beyond the expiration date stated on the label.

Forschungsgebiet: Neurologie, Alzheimer-Krankheit (Morbus Alzheimer)

Beschränkungen: Für Forschungszwecke. Als CE-zertifizierter Antikörper in der Europäischen Union für In Vitro Diagnostik (IVD) zugelassen.

Publikationen

Publikationen: Tanzi, McClatchey, Lamperti et al.: "Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease." in: Nature, Vol. 331, Issue 6156, pp. 528-30, 1988 (PubMed).