CD358 / DR6 Antikörper

Antigen: CD358 / DR6

Klonalität: Monoklonal (DR-6-04-EC)

Wirt: Maus

Reaktivität: Human

Applikation: Durchflusszytometrie (FACS), Immunpräzipitation (IP), Immunzytochemie (ICC)

Produktnummer: ABIN94305

Produktbeschreibung

Immunogen: A fusion protein representing amino acids 42-335 (extracellular part) of human DR6 linked tothe Fc portion of human IgG1 was used as an immunogen.

Format: Purified

Isotyp: IgG1  (Passende Sekundärantikörper)

Klon: DR-6-04-EC

Beschreibung: CD358 / DR6 (Death Receptor-6) is a type I transmembrane protein of the TNF receptorsuperfamily, expressed in most human tissues and able of inducing apoptosis through itscytoplasmic death domain. Unlike TNFR1 and Fas, DR6 induces apoptosis independently ofFADD adaptor. In immune system, DR6 serves as an important regulator for CD4+ T cellproliferation and Th differentiation, and provides also a regulatory mechanism for B cellactivation and humoral immune responses.

Spezifität: The antibody DR-6-04-EC recognizes human DR6 (Death receptor-6), a type Itransmembrane protein containing cytoplasmic death domain, widely expressed in mosthuman tissues and cell lines.

Anwendungen

Applikationshinweise: Immunoprecipitation. Application note: The antibody DR-6-04-EC immunoprecipitates overexpressed DR6 from DR6-transfectedHEK/293 cells.

Konzentration: 1 mg/ml

Reinheit: > 95% (by SDS-PAGE)

Reinigung: Purified from hybridoma culture supernatant by protein A-affinity chromatography.

Buffer: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4

Lagerung: Store at 2-8 o C. Do not use after expiration date stamped on vial label. For long-term storage aliquot and store at -20 o C. Avoid freeze/thaw cycles.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

Flow Cytometry analysis