Basal Cellmarker Cocktail P63 Protein/HMW Cytokeratin Antikörper

Antigen: Basal Cellmarker Cocktail P63 Protein/HMW Cytokeratin

Klonalität: Monoklonal (4A4-34betaE12)

Wirt: Maus

Reaktivität: Human

Applikation: Immunhistochemie (Paraffinschnitte) (IHC (p))

Produktnummer: ABIN93860

Produktbeschreibung

Weitere Bezeichnung: Basal Cellmarker Cocktail p63 Protein + HMW Cytokeratin

Immunogen: Recombinant human p63 protein (aa 1-205) and cytokeratin extract of human stratum corneum

Format: Ready to use

Isotyp: IgG2a + IgG1  (Passende Sekundärantikörper)

Klon: 4A4-34betaE12

Beschreibung: Antibody solution in stabilizing phosphate buffer pH 7.3. Contains 0.09 % sodium azide**. The volume is sufficient for at least 50 immunohistochemical tests (100 ul working solution / test). Use appropriate antibody diluent.

Spezifität: Nuclear p63 and cytoplasmic high molecular weight cytokeratins

Anwendungen

Applikationshinweise: IHC(P) , neat , Positive Control: Normal prostate tissue or skin

Konzentration: 0,5+0,5

Buffer: Antibody solution in stabilizing phosphate buffer pH 7.3. Contains 0.09 % sodium azide. The volume is sufficient for at least 50 immunohistochemical tests (100 µl working solution / test)

Lagerung: 2-8°C

Forschungsgebiet: Krebs, Signaltransduktion, Apoptose/Nekrose

Beschränkungen: Nur für Forschungszwecke einsetzbar

Publikationen

Publikationen: Yang XJ, Lecksell K, Gaudin P et al.: "Rare expression of high-molecular-weight cytokeratin in adenocarcinoma of the prostate gland: a study of 100 cases of metastatic and locally advanced prostate cancer." in: Am J Surg Pathol, Vol. 23, Issue 2, pp. 147-52, 1999 (PubMed).

Signoretti, Waltregny, Dilks et al.: "p63 is a prostate basal cell marker and is required for prostate development." in: The American journal of pathology, Vol. 157, Issue 6, pp. 1769-75, 2000 (PubMed).

Weinstein MH, Signoretti S, Loda M: "Diagnostic utility of immunohistochemical staining for p63, a sensitive marker of prostatic basal cells." in: Mod Pathol, Vol. 15, Issue 12, pp. 1302-8, 2002 (PubMed).

Browne TJ, Hirsch MS, Brodsky G et al.: "Prospective evaluation of AMACR (P504S) and basal cell markers in the assessment of routine prostate needle biopsy specimens." in: Hum Pathol, Vol. 35, Issue 12, pp. 1462-8, 2004 (PubMed).