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WNK3 Antikörper (AA 451-550) (Alexa Fluor 488)

WNK3 Reaktivität: Human, Ratte WB, IF (cc), IF (p) Wirt: Kaninchen Polyclonal Alexa Fluor 488
Produktnummer ABIN920029
  • Target Alle WNK3 Antikörper anzeigen
    WNK3 (WNK Lysine Deficient Protein Kinase 3 (WNK3))
    Bindungsspezifität
    • 14
    • 7
    • 7
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 451-550
    Reaktivität
    • 48
    • 25
    • 13
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Ratte
    Wirt
    • 47
    • 3
    Kaninchen
    Klonalität
    • 48
    • 2
    Polyklonal
    Konjugat
    • 17
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser WNK3 Antikörper ist konjugiert mit Alexa Fluor 488
    Applikation
    • 27
    • 23
    • 16
    • 12
    • 12
    • 5
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Kreuzreaktivität
    Human, Ratte
    Homologie
    Mouse,Cow,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human WNK3 protein
    Isotyp
    IgG
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  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    WNK3 (WNK Lysine Deficient Protein Kinase 3 (WNK3))
    Andere Bezeichnung
    Wnk3 Protein (WNK3 Produkte)
    Synonyme
    fc63h12 antikoerper, PRKWNK3 antikoerper, Prkwnk3 antikoerper, Wnk3-ps antikoerper, RGD1563131 antikoerper, wu:fc63h12 antikoerper, WNK lysine deficient protein kinase 3 antikoerper, wu:fc63h12 antikoerper, LOC100363278 antikoerper, WNK3 antikoerper, Wnk3 antikoerper
    Hintergrund

    Synonyms: PRKWNK3, Serine/threonine-protein kinase WNK3, Protein kinase lysine-deficient 3, Protein kinase with no lysine 3, WNK3, KIAA1566

    Background: Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Phosphorylates WNK4. Regulates the phosphorylation of SLC12A1 and SLC12A2. Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway. Inhibits the activity of KCNJ1 by decreasing its expression at the cell membrane in a non-catalytic manner. Isoform 1, isoform 2, isoform 3 and isoform 4 stimulate the activity of SLC12A1, SLC12A2 and SLC12A3 and inhibit the activity of SLC12A4, SLC12A5, SLC12A6 and SLC12A7. According to PubMed:19470686, isoform 1 inhibits the activity of SLC12A3.

    Gen-ID
    65267
    UniProt
    Q9BYP7
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