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NLRP4 Antikörper (AA 351-450) (Alexa Fluor 647)

NLRP4 Reaktivität: Human, Ratte IF (cc), IF (p) Wirt: Kaninchen Polyclonal Alexa Fluor 647
Produktnummer ABIN907630
  • Target Alle NLRP4 Antikörper anzeigen
    NLRP4 (NLR Family, Pyrin Domain Containing 4 (NLRP4))
    Bindungsspezifität
    • 14
    • 8
    • 7
    • 6
    • 1
    • 1
    AA 351-450
    Reaktivität
    • 32
    • 14
    • 2
    Human, Ratte
    Wirt
    • 32
    Kaninchen
    Klonalität
    • 32
    Polyklonal
    Konjugat
    • 9
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser NLRP4 Antikörper ist konjugiert mit Alexa Fluor 647
    Applikation
    • 18
    • 16
    • 12
    • 12
    • 4
    • 4
    • 1
    • 1
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Spezifität
    This antibody will detect multiple forms of NALP4, including the A, C and E Mouse variants.
    Kreuzreaktivität
    Human, Ratte
    Homologie
    Mouse,Pig,Horse
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human NALP4
    Isotyp
    IgG
    Top Product
    Discover our top product NLRP4 Primärantikörper
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    NLRP4 (NLR Family, Pyrin Domain Containing 4 (NLRP4))
    Andere Bezeichnung
    NALP4 (NLRP4 Produkte)
    Synonyme
    CLR19.5 antikoerper, CT58 antikoerper, NALP4 antikoerper, PAN2 antikoerper, PYPAF4 antikoerper, RNH2 antikoerper, Nalp4 antikoerper, Nlrp4e antikoerper, RGD1563529 antikoerper, NLR family pyrin domain containing 4 antikoerper, NLR family, pyrin domain containing 4 antikoerper, NLRP4 antikoerper, Nlrp4 antikoerper
    Hintergrund

    Synonyms: NACHT, LRR and PYD domains-containing protein 4, Cancer/testis antigen 58, CT58, PAAD and NACHT-containing protein 2, PAN2, PYRIN and NACHT-containing protein 2, PYRIN-containing APAF1-like protein 4, PYPAF4, Ribonuclease inhibitor 2, NLRP4, NALP4, RNH2

    Background: May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors. Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation. Suppresses NF-kappaB induction by the cytokines TNFA and IL1B, suggesting that it operates at a point of convergence in these two cytokine signaling pathways.

    Gen-ID
    147945
    UniProt
    Q96MN2
    Pathways
    Inflammasome
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