NSD1 Antikörper (AA 2401-2600) (Alexa Fluor 488)

Produktnummer ABIN904260

Produktdetails anti-NSD1 Antikörper (Alexa Fluor 488)

Target: NSD1 (Nuclear Receptor Binding SET Domain Protein 1 (NSD1))

Bindungsspezifität: AA 2401-2600

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NSD1 Antikörper ist konjugiert mit Alexa Fluor 488

Applikation: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Dog,Cow,Sheep,Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human NSD1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu NSD1

Target: NSD1 (Nuclear Receptor Binding SET Domain Protein 1 (NSD1))

Andere Bezeichnung: NSD1 (NSD1 Produkte)

Synonyme: NSD1 antikoerper, sto antikoerper, kmt3b antikoerper, sotos antikoerper, ara267 antikoerper, ARA267 antikoerper, KMT3B antikoerper, SOTOS antikoerper, SOTOS1 antikoerper, STO antikoerper, AI528500 antikoerper, nuclear receptor binding SET domain protein 1 antikoerper, histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific antikoerper, nuclear receptor-binding SET-domain protein 1 antikoerper, NSD1 antikoerper, nsd1 antikoerper, Nsd1 antikoerper, LOC540197 antikoerper

Hintergrund:

Synonyms: Androgen receptor coactivator 267 kDa protein, Androgen receptor-associated protein of 267 kDa, ARA267, H3 K36 HMTase, H3-K36-HMTase, H4 K20 HMTase, H4-K20-HMTase, Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specic, KMT3B, Lysine N-methyltransferase 3B, NR binding SET domain containing protein, NR-binding SET domain-containing protein, Nsd1, NSD1_HUMAN, Nuclear receptor binding SET domain containing protein 1, Nuclear receptor-binding SET domain-containing protein 1.

Background: This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].

Gen-ID: 64324