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KCNMB1 Antikörper (AA 10-80) (Alexa Fluor 555)

KCNMB1 Reaktivität: Ratte IF (cc), IF (p) Wirt: Kaninchen Polyclonal Alexa Fluor 555
Produktnummer ABIN903515
  • Target Alle KCNMB1 Antikörper anzeigen
    KCNMB1 (Potassium Large Conductance Calcium-Activated Channel, Subfamily M, beta Member 1 (KCNMB1))
    Bindungsspezifität
    • 14
    • 8
    • 8
    • 7
    • 6
    • 5
    • 1
    • 1
    AA 10-80
    Reaktivität
    • 31
    • 15
    • 10
    Ratte
    Wirt
    • 45
    Kaninchen
    Klonalität
    • 45
    Polyklonal
    Konjugat
    • 11
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser KCNMB1 Antikörper ist konjugiert mit Alexa Fluor 555
    Applikation
    • 21
    • 19
    • 12
    • 12
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Kreuzreaktivität
    Ratte
    Homologie
    Human,Mouse,Cow,Sheep,Pig,Horse
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human KCNMB1
    Isotyp
    IgG
    Top Product
    Discover our top product KCNMB1 Primärantikörper
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    KCNMB1 (Potassium Large Conductance Calcium-Activated Channel, Subfamily M, beta Member 1 (KCNMB1))
    Andere Bezeichnung
    KCNMB1 (KCNMB1 Produkte)
    Synonyme
    KCNMB1 antikoerper, BKbeta1 antikoerper, K(VCA)beta antikoerper, SLO-BETA antikoerper, hbeta1 antikoerper, hslo-beta antikoerper, k(VCA)beta-1 antikoerper, slo-beta-1 antikoerper, BKBETA antikoerper, potassium calcium-activated channel subfamily M regulatory beta subunit 1 antikoerper, potassium large conductance calcium-activated channel, subfamily M, beta member 1 antikoerper, KCNMB1 antikoerper, Kcnmb1 antikoerper
    Hintergrund

    Synonyms: Calcium-activated potassium channel subunit beta-1, KCNMB1, BK channel subunit beta-1, Charybdotoxin receptor subunit beta-1, K(VCA)beta-1, Maxi K channel subunit beta-1, Slo-beta-1, Slo-beta

    Background: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca2+/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate.

    Gen-ID
    3779
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