FAP Antikörper (AA 311-410) (Alexa Fluor 647)

Produktnummer ABIN896768

Produktdetails anti-FAP Antikörper (Alexa Fluor 647)

Target: FAP (Fibroblast Activation Protein, alpha (FAP))

Bindungsspezifität: AA 311-410

Reaktivität: Human, Maus, Rind (Kuh)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FAP Antikörper ist konjugiert mit Alexa Fluor 647

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Rind (Kuh), Human, Maus

Homologie: Rat,Dog,Cow,Pig,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human FAPA

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-FAP Antikörper (Alexa Fluor 647) (ABIN896768)

Miller, Nagy, Knapp, Laengle, Ponweiser, Groeger, Starkl, Bergmann, Wagner, Haschemi: "Exploring Metabolic Configurations of Single Cells within Complex Tissue Microenvironments." in: Cell metabolism, Vol. 26, Issue 5, pp. 788-800.e6, (2017) (PubMed).

Evrard, Lecce, Michelis, Nomura-Kitabayashi, Pandey, Purushothaman, dEscamard, Li, Hadri, Fujitani, Moreno, Benard, Rimmele, Cohain, Mecham, Randolph, Nabel, Hajjar, Fuster, Boehm, Kovacic: "Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability." in: Nature communications, Vol. 7, pp. 11853, (2016) (PubMed).

Details zu FAP

Target: FAP (Fibroblast Activation Protein, alpha (FAP))

Andere Bezeichnung: FAPA (FAP Produkte)

Synonyme: fap-A antikoerper, gene 13 antikoerper, FAP antikoerper, fapa antikoerper, dppiv antikoerper, seprase antikoerper, DPPIV antikoerper, FAPA antikoerper, fibroblast activation protein antikoerper, fibroblast activation protein alpha L homeolog antikoerper, fibroblast activation protein alpha antikoerper, fibroblast activation protein, alpha antikoerper, prolyl endopeptidase FAP antikoerper, Fap antikoerper, fap.L antikoerper, FAP antikoerper, fap antikoerper, LOC100547273 antikoerper

Hintergrund:

Synonyms: FAPA, DPPIV, Prolyl endopeptidase FAP, 17 kDa melanoma membrane-bound gelatinase, Dipeptidyl peptidase FAP, Fibroblast activation protein alpha, FAPalpha, Gelatine degradation protease FAP, Integral membrane serine protease, Post-proline cleaving enzyme, Serine integral membrane protease, SIMP, Surface-expressed protease, Seprase, FAP

Background: In association with DPP4 is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May have a role in tissue remodeling during development and wound healing, and may contribute to invasiveness in malignant cancers.

Gen-ID: 2191

UniProt: Q12884

Pathways: Tube Formation