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SMARCA4 Antikörper (AA 701-705)

SMARCA4 Reaktivität: Human, Maus, Ratte WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN871762
  • Target Alle SMARCA4 Antikörper anzeigen
    SMARCA4 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 (SMARCA4))
    Bindungsspezifität
    • 16
    • 5
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 701-705
    Reaktivität
    • 73
    • 42
    • 42
    • 2
    • 2
    • 2
    • 1
    Human, Maus, Ratte
    Wirt
    • 59
    • 12
    • 2
    • 2
    Kaninchen
    Klonalität
    • 50
    • 25
    Polyklonal
    Konjugat
    • 42
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SMARCA4 Antikörper ist unkonjugiert
    Applikation
    • 37
    • 20
    • 15
    • 15
    • 15
    • 14
    • 13
    • 13
    • 13
    • 8
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    Western Blotting (WB)
    Spezifität
    The antibody detects endogenous level of total Brg1 protein.
    Aufreinigung
    Affinity purified
    Immunogen
    Peptide sequence around AA 701-705 (V-D-A-R-H) derived from Human Brg1. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
    Top Product
    Discover our top product SMARCA4 Primärantikörper
  • Applikationshinweise
    Western blotting: 1:500-1:1000  
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
  • Target
    SMARCA4 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 (SMARCA4))
    Andere Bezeichnung
    Brg1 (SMARCA4 Produkte)
    Synonyme
    SMARCA4 antikoerper, BAF190 antikoerper, BAF190A antikoerper, BRG1 antikoerper, MRD16 antikoerper, RTPS2 antikoerper, SNF2 antikoerper, SNF2L4 antikoerper, SNF2LB antikoerper, SWI2 antikoerper, hSNF2b antikoerper, brg-1 antikoerper, Brg1 antikoerper, HP1-BP72 antikoerper, SNF2beta antikoerper, SW1/SNF antikoerper, b2b692Clo antikoerper, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 antikoerper, SMARCA4 antikoerper, Smarca4 antikoerper
    Hintergrund
    Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1.
    Molekulargewicht
    200 kDa
    Gen-ID
    6597
    NCBI Accession
    NP_001122
    UniProt
    P51532
    Pathways
    Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Stem Cell Maintenance
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