DC-SIGN/CD209 Antikörper (AA 389-393)

Produktnummer ABIN871703

Produktdetails anti-DC-SIGN/CD209 Antikörper

Target: DC-SIGN/CD209 (CD209) (CD209)

Bindungsspezifität: AA 389-393

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DC-SIGN/CD209 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: The antibody detects endogenous level of total CD209 (DC-SIGN) protein.

Aufreinigung: Affinity purified

Immunogen: Peptide sequence around AA 389-393 ( E-Q-F-L-S ) derived from Human CD209 (DC-SIGN) . Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.

Anwendungsinformationen

Applikationshinweise: Western blotting: 1:500-1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Details zu DC-SIGN/CD209

Target: DC-SIGN/CD209 (CD209) (CD209)

Andere Bezeichnung: CD209 (DC-SIGN) (CD209 Produkte)

Synonyme: CDSIGN antikoerper, CLEC4L antikoerper, DC-SIGN antikoerper, DC-SIGN1 antikoerper, cd209 antikoerper, CLEC4M antikoerper, si:ch211-224h1.3 antikoerper, CD209 antikoerper, CIRE antikoerper, Dcsign antikoerper, SIGN-R1 antikoerper, SIGNR5 antikoerper, Cd209 antikoerper, CD209 molecule antikoerper, CD209a antigen antikoerper, CD209 antigen-like protein D antikoerper, CD209c molecule antikoerper, CD209 antigen antikoerper, CD209 antikoerper, cd209 antikoerper, Cd209a antikoerper, LOC100529184 antikoerper, Cd209c antikoerper, LOC100460708 antikoerper, LOC105484282 antikoerper

Hintergrund: Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, cytomegalovirus gB, HCV E2, dengue virus gE, Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri-mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA. On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells.

Molekulargewicht: 46 kDa

Gen-ID: 30835

NCBI Accession: NP_066978

UniProt: Q9NNX6