Synaptophysin 2 Antikörper (AA 257-261)

Produktnummer ABIN871665

Produktdetails anti-Synaptophysin 2 Antikörper

Target: Synaptophysin 2

Bindungsspezifität: AA 257-261

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Synaptophysin 2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: The antibody detects endogenous levels of total synaptophysin 2 protein.

Aufreinigung: Affinity purified

Immunogen: Peptide sequence around AA 257-261 (G-P-T-S-F) derived from Rat synaptophysin 2. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.

Anwendungsinformationen

Applikationshinweise: Western blotting: 1:500-1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Details zu Synaptophysin 2

Target: Synaptophysin 2

Abstract: Synaptophysin 2 Produkte

Synonyme: synaptoporin antikoerper, Synpr antikoerper

Hintergrund: Synaptophysin (SYP) is a neuronal synaptic vesicle glycoprotein that is expressed in neuroendocrine cells and neoplasms, and thus can be used as a marker in tumor diagnosis (1). Synaptophysin contains four transmembrane domains that form a hexameric channel or gap junction-like pore (2). Synaptophysin binds to the SNARE protein synaptobrevin/VAMP, which prevents the inclusion of synaptobrevin in the synaptic vesicle fusion complex and creates a pool of synaptobrevin for exocytosis when synapse activity increases (3). Synaptophysin is also responsible for targeting synaptobrevin 2/VAMP2 to synaptic vesicles, a critical component of the fusion complex

Molekulargewicht: 37 kDa

Gen-ID: 66030

NCBI Accession: NP_076464

UniProt: P22831