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LIN28A Antikörper (AA 1-5)

LIN28A Reaktivität: Human, Maus, Ratte WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN871652
  • Target Alle LIN28A Antikörper anzeigen
    LIN28A (Lin-28 Homolog A (C. Elegans) (LIN28A))
    Bindungsspezifität
    • 15
    • 9
    • 9
    • 7
    • 7
    • 7
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-5
    Reaktivität
    • 103
    • 29
    • 21
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 82
    • 23
    Kaninchen
    Klonalität
    • 75
    • 30
    Polyklonal
    Konjugat
    • 50
    • 9
    • 7
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser LIN28A Antikörper ist unkonjugiert
    Applikation
    • 69
    • 41
    • 30
    • 22
    • 16
    • 14
    • 14
    • 13
    • 10
    • 9
    • 7
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB)
    Spezifität
    The antibody detects endogenous levels of total Lin28 protein.
    Aufreinigung
    Affinity purified
    Immunogen
    Peptide sequence around AA 1-5 (M-G-S-V-S) derived from Human Lin28 Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
    Top Product
    Discover our top product LIN28A Primärantikörper
  • Applikationshinweise
    Western blotting: 1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
  • Target
    LIN28A (Lin-28 Homolog A (C. Elegans) (LIN28A))
    Andere Bezeichnung
    Lin28 (LIN28A Produkte)
    Synonyme
    CSDD1 antikoerper, LIN-28 antikoerper, LIN28 antikoerper, ZCCHC1 antikoerper, lin-28A antikoerper, AL024421 antikoerper, ENSMUSG00000070700 antikoerper, Gm10299 antikoerper, Lin-28 antikoerper, Lin28 antikoerper, Tex17 antikoerper, csdd1 antikoerper, lin-28 antikoerper, lin28 antikoerper, zcchc1 antikoerper, sb:cb650 antikoerper, zgc:55584 antikoerper, RGD1566408 antikoerper, lin-28 homolog A antikoerper, lin-28 homolog A (C. elegans) antikoerper, lin-28 homolog A S homeolog antikoerper, LIN28A antikoerper, Lin28a antikoerper, lin28a.S antikoerper, lin28a antikoerper
    Hintergrund
    Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression. Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells.
    Molekulargewicht
    26 kDa
    Gen-ID
    79727
    NCBI Accession
    NP_078950
    UniProt
    Q9H9Z2
    Pathways
    Stem Cell Maintenance
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