SHANK2 Antikörper (AA 84-309)

Produktnummer ABIN863120

Produktdetails anti-SHANK2 Antikörper

Target: SHANK2 (SH3 and Multiple Ankyrin Repeat Domains 2 (SHANK2))

Bindungsspezifität: AA 84-309

Reaktivität: Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SHANK2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF), Immunocytochemistry (ICC), Antibody Array (AA)

Spezifität: Detects ~160 kDa. Recognizes Shank1, 2 and 3.

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Protein G Purified

Immunogen: Fusion protein amino acids 84-309 of rat Shank2

Klon: N23b-49 (Formerly S23b-49)

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

• WB (1:1000)
• IHC (1:1000)
• ICC/IF (1:100)
• optimal dilutions for assays should be determined by the user.

Kommentare:

1 μg/ml of ABIN863120 was sufficient for detection of Shank1-4 in 10 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C

Referenzen für anti-SHANK2 Antikörper (ABIN863120)

Nagura, Ishikawa, Kobayashi, Takao, Tanaka, Nishikawa, Tamura, Shiosaka, Suzuki, Miyakawa, Fujiyoshi, Doi et al.: "Impaired synaptic clustering of postsynaptic density proteins and altered signal transmission in hippocampal neurons, and disrupted learning behavior in PDZ1 and PDZ2 ligand binding-deficient PSD-95 ..." in: Molecular brain, Vol. 5, pp. 43, (2013) (PubMed).

Details zu SHANK2

Target: SHANK2 (SH3 and Multiple Ankyrin Repeat Domains 2 (SHANK2))

Andere Bezeichnung: SHANK (SHANK2 Produkte)

Synonyme: AUTS17 antikoerper, CORTBP1 antikoerper, CTTNBP1 antikoerper, ProSAP1 antikoerper, SHANK antikoerper, SPANK-3 antikoerper, mKIAA1022 antikoerper, auts17 antikoerper, cortbp1 antikoerper, cttnbp1 antikoerper, prosap1 antikoerper, spank-3 antikoerper, shank2 antikoerper, MGC122482 antikoerper, CortBP1 antikoerper, Spank-3 antikoerper, SHANK2 antikoerper, SH3 and multiple ankyrin repeat domains 2 antikoerper, SH3 and multiple ankyrin repeat domains 2 L homeolog antikoerper, SH3 and multiple ankyrin repeat domains protein 2 antikoerper, SHANK2 antikoerper, Shank2 antikoerper, shank2.L antikoerper, shank2 antikoerper, LOC100438523 antikoerper

Hintergrund: Shank proteins make up a family of scaffold proteins identified through their interaction with a variety of membrane and cytoplasmic proteins (1). Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. Studies suggest that Shank2 is expressed in the neurons of the developing retina, and could play a role in the neuronal differentiation of the developing retina (2). Other recent studies suggest that the disruption of glutamate receptors at the Shank postsynaptic platform could contribute to the destruction of the postsynaptic density, which underlies the synaptic dysfunction and loss in Alzheimer's disease (3).

Gen-ID: 171093

UniProt: Q9QX74