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Ptges3l Antikörper

PTGES3L Reaktivität: Human WB, IHC, AA Wirt: Maus Monoclonal Tsp232A unconjugated
Produktnummer ABIN863111
  • Target Alle Ptges3l (PTGES3L) Produkte
    Ptges3l (PTGES3L) (Prostaglandin E Synthase 3 (Cytosolic)-Like (PTGES3L))
    Reaktivität
    • 21
    • 11
    Human
    Wirt
    • 21
    Maus
    Klonalität
    • 20
    Monoklonal
    Konjugat
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Dieser Ptges3l Antikörper ist unkonjugiert
    Applikation
    Western Blotting (WB), Immunohistochemistry (IHC), Antibody Array (AA)
    Spezifität
    Detects ~19 kDa. Detects Tsp23, no cross-reactivity to p23.
    Kreuzreaktivität
    Human, Maus
    Aufreinigung
    Protein G Purified
    Immunogen
    Recombinant tsp23
    Klon
    Tsp232A
    Isotyp
    IgG1 kappa
  • Applikationshinweise
    • WB (1:1000)
    • IHC (1:1000)
    • optimal dilutions for assays should be determined by the user.
    Kommentare

    1 μg/ml of ABIN863111 was sufficient for detection of tsp23 in 20 μg of transiently transfected Hela cell lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    -20°C
  • Target
    Ptges3l (PTGES3L) (Prostaglandin E Synthase 3 (Cytosolic)-Like (PTGES3L))
    Andere Bezeichnung
    TSP23 (PTGES3L Produkte)
    Synonyme
    1110069E20Rik antikoerper, 1700113I22Rik antikoerper, prostaglandin E synthase 3 like antikoerper, Ptges3l antikoerper, PTGES3L antikoerper
    Hintergrund
    P23 is a highly conserved ubiquitous protein, known to have an important function as a cochaperone for the HSP90 chaperoning system (1). Studies have revealed that p23 is a small protein (18 to 25 kDa) with a simple structure (2, 3). p23 is a phosphor-protein, which is highly acidic and has an aspartic acid-rich c-terminal domain (1). Numerous studies have found p23 to be associated with other client proteins like Fes tyrosine kinase (4), the heme regulated kinase HRI (5), hsf1 transcription factor (4), aryl hydrocarbon receptor (4), telomerase (6), and Hepadnavirus reverse transcriptase (7). In spite of several years of study, the exact functional significance of p23 is still not clear (8). p23 is thought to be involved in the adenosine triphosphate-mediated HSP90 binding of client proteins (8). Since many HSP90 client proteins are involved in oncogenic survival signaling, a recent study has concluded p23 to be a promising target in leukemic apoptosis (9). HSP90 and its co-chaperone p23 are certainly among the emerging anti-tumor targets in oncology. Specifically TSP23 (transcript similar p23) displays 44 % and 17 % amino acid identity with p23 and Sba1p respectively (10).
    Gen-ID
    80755
    NCBI Accession
    NP_001136126
    UniProt
    B9A003
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