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Endoglin Antikörper (Biotin)

ENG Reaktivität: Human, Schwein WB, FACS, ICC, IHC (fro) Wirt: Maus Monoclonal MEM-229 Biotin
Produktnummer ABIN810077
  • Target Alle Endoglin (ENG) Antikörper anzeigen
    Endoglin (ENG)
    Reaktivität
    • 177
    • 67
    • 44
    • 17
    • 9
    • 3
    • 2
    • 1
    Human, Schwein
    Wirt
    • 107
    • 92
    • 21
    • 1
    • 1
    Maus
    Klonalität
    • 114
    • 107
    • 1
    Monoklonal
    Konjugat
    • 93
    • 27
    • 26
    • 26
    • 15
    • 9
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Endoglin Antikörper ist konjugiert mit Biotin
    Applikation
    • 152
    • 133
    • 62
    • 58
    • 37
    • 21
    • 19
    • 14
    • 14
    • 13
    • 13
    • 7
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Spezifität
    The antibody MEM-229 recognizes an extracellular epitope of CD105 (Endoglin), a 90 kDa type I integral membrane homodimer glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow, it is also present on syncytiotrophoblast on placenta throughout pregnancy.
    Keine Kreuzreaktivität
    Hund, Pferd
    Kreuzreaktivität (Details)
    Human, Porcine
    Aufreinigung
    Purified antibody is conjugated with biotin LC-NHS ester under optimum conditions and unconjugated antibody and free biotin are removed by size-exclusion chromatography.
    Immunogen
    Recombinant Vaccinia virus containing the human CD105 (L-isoform) cDNA.
    Klon
    MEM-229
    Isotyp
    IgG2a
    Top Product
    Discover our top product ENG Primärantikörper
  • Applikationshinweise
    Flow cytometry: Recommended dilution: 8 μg/mL, positive control: Kg1 human acute myelogenous leukemia cell line.
    Kommentare

    The purified antibody is conjugated with Biotin-LC-NHS under optimum conditions. The reagent is free of unconjugated biotin.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1 mg/mL
    Buffer
    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Do not freeze.
    Avoid prolonged exposure to light.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store at 2-8°C. Do not freeze.
  • Plánka, Necas, Srnec, Rauser, Starý, Jancár, Amler, Filová, Hlucilová, Kren, Gál: "Use of allogenic stem cells for the prevention of bone bridge formation in miniature pigs." in: Physiological research / Academia Scientiarum Bohemoslovaca, Vol. 58, Issue 6, pp. 885-93, (2010) (PubMed).

  • Target
    Endoglin (ENG)
    Andere Bezeichnung
    CD105 (ENG Produkte)
    Synonyme
    ENG antikoerper, MGC137842 antikoerper, DKFZp469D0419 antikoerper, END antikoerper, HHT1 antikoerper, ORW1 antikoerper, AI528660 antikoerper, AI662476 antikoerper, CD105 antikoerper, S-endoglin antikoerper, endoglin antikoerper, ENG antikoerper, Eng antikoerper
    Hintergrund
    Endoglin,CD105 (endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.,Endoglin, END, ENG, HHT1, ORW1
    Gen-ID
    2022
    UniProt
    P17813
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