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NMDAR2A Antikörper (pTyr1325)

GRIN2A Reaktivität: Ratte, Maus WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN784606
  • Target Alle NMDAR2A (GRIN2A) Antikörper anzeigen
    NMDAR2A (GRIN2A) (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2a (GRIN2A))
    Bindungsspezifität
    • 44
    • 28
    • 24
    • 15
    • 13
    • 12
    • 9
    • 8
    • 8
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pTyr1325
    Reaktivität
    • 141
    • 114
    • 96
    • 10
    • 10
    • 8
    • 6
    • 2
    • 2
    • 2
    • 1
    • 1
    Ratte, Maus
    Wirt
    • 149
    • 51
    • 1
    Kaninchen
    Klonalität
    • 140
    • 61
    Polyklonal
    Konjugat
    • 68
    • 14
    • 14
    • 12
    • 10
    • 8
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser NMDAR2A Antikörper ist unkonjugiert
    Applikation
    • 160
    • 99
    • 46
    • 31
    • 28
    • 26
    • 26
    • 22
    • 16
    • 15
    • 13
    • 9
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB)
    Spezifität
    Specific for the ~180k NMDAR NR2A-subunit protein phosphorylated at Tyr1325 in Western blots. Immunolabeling is completely blocked by blocked by the phosphopeptide used as the antigen but not by the corresponding dephosphopeptide.
    Kreuzreaktivität (Details)
    Species reactivity (expected):Bovine and CanineSpecies reactivity (tested):Mouse and Rat.
    Aufreinigung
    Affinity Chromatography.
    Immunogen
    Phosphopeptide corresponding to amino acid residues surrounding the phospho-Tyr1325 of NMDA NR2A.
    Isotyp
    IgG
    Top Product
    Discover our top product GRIN2A Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store the antibody undiluted (in aliquots) at -20 °C.
  • Target
    NMDAR2A (GRIN2A) (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2a (GRIN2A))
    Abstract
    GRIN2A Produkte
    Synonyme
    NMDAR2A antikoerper, nr2a antikoerper, GRIN2A antikoerper, EPND antikoerper, GluN2A antikoerper, NR2A antikoerper, glutamate ionotropic receptor NMDA type subunit 2A antikoerper, glutamate receptor, ionotropic, N-methyl D-aspartate 2A L homeolog antikoerper, glutamate receptor ionotropic, NMDA 2A antikoerper, glutamate receptor, ionotropic, NMDA2A (epsilon 1) antikoerper, GRIN2A antikoerper, grin2a.L antikoerper, LOC100438553 antikoerper, Grin2a antikoerper
    Hintergrund
    The ion channels activated by glutamate that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's, epilepsy and ischemic neuronal cell death (Grosshans et al., 2002, Wenthold et al., 2003, Carroll and Zukin, 2002). The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS (Lovinger et al., 1989, Alvestad et al., 2003, Snell et al., 1996). Channels with physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits (Ishii et al., 1993). Recently, phosphorylation of Tyrosine 1325 of the NR2A subunit has been shown to be increased in human brain tissue sections from HIV-infected individuals with encephalitis (King et al., 2010). In addition, Tyr1325 phosphorylation has been linked with depression-related behavior (Taniguchi et al., 2009).Synonyms: GRIN2A, Glutamate [NMDA] Receptor subunit epsilon-1, NMDAR2A, NR2A
    Gen-ID
    24409
    NCBI Accession
    NP_036705
    Pathways
    Synaptic Membrane, Regulation of long-term Neuronal Synaptic Plasticity
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