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NLRP12 Antikörper (N-Term)

NLRP12 Reaktivität: Human, Maus, Ratte WB, EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN783719
  • Target Alle NLRP12 Antikörper anzeigen
    NLRP12 (NLR Family, Pyrin Domain Containing 12 (NLRP12))
    Bindungsspezifität
    • 15
    • 8
    • 8
    • 8
    • 7
    • 5
    • 2
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 51
    • 17
    • 15
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 49
    • 4
    • 1
    Kaninchen
    Klonalität
    • 50
    • 4
    Polyklonal
    Konjugat
    • 20
    • 5
    • 5
    • 5
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser NLRP12 Antikörper ist unkonjugiert
    Applikation
    • 36
    • 33
    • 14
    • 13
    • 13
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Spezifität
    This antibody detects NALP2 at N-term.
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human, mouse, rat
    Aufreinigung
    Affinity chromatography purified via peptide column
    Immunogen
    18 amino acid peptide near the amino terminus of human NALP12
    Top Product
    Discover our top product NLRP12 Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS containing 0.02 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
  • Target
    NLRP12 (NLR Family, Pyrin Domain Containing 12 (NLRP12))
    Andere Bezeichnung
    NALP12 (NLRP12 Produkte)
    Synonyme
    Nalp12 antikoerper, NALP12 antikoerper, CLR19.3 antikoerper, FCAS2 antikoerper, PAN6 antikoerper, PYPAF7 antikoerper, RNO antikoerper, RNO2 antikoerper, NLR family, pyrin domain containing 12 antikoerper, NLR family pyrin domain containing 12 antikoerper, NACHT, LRR and PYD domains-containing protein 3 antikoerper, Nlrp12 antikoerper, NLRP12 antikoerper, LOC100018508 antikoerper
    Hintergrund
    NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP12, also known as Monarch-1, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. NALP12 is thought to act as an attenuating factor of inflammation by suppressing inflammatory responses such as NF-kB activation by TLR-signaling molecules MyD88, IRAK-1, TRAF6 and RIPK1 in activated monocytes. Recent evidence suggests that mutations in NALP12 result in hereditary periodic fever syndromes.Synonyms: LRR and PYD domains-containing protein 12, Monarch-1, NACHT, NLRP12, PYPAF7, PYRIN-containing APAF1-like protein 7, RNO, Regulated by nitric oxide
    Gen-ID
    91662
    NCBI Accession
    NP_150639
    UniProt
    P59046
    Pathways
    Positive Regulation of Endopeptidase Activity, Inflammasome
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