ATP2C2 Antikörper (N-Term)

Produktnummer ABIN783440

Produktdetails anti-ATP2C2 Antikörper

Target: ATP2C2 (ATPase, Ca++ Transporting, Type 2C, Member 2 (ATP2C2))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ATP2C2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Spezifität: This antibody detects ATP2C2 at N-term. At least three isoforms of ATP2C2 are known to exist. ATP2C2 antibody will not cross-react with ATP2C1.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 19 amino acid peptide near the amino terminus of human ATP2C2

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu ATP2C2

Target: ATP2C2 (ATPase, Ca++ Transporting, Type 2C, Member 2 (ATP2C2))

Andere Bezeichnung: ATP2C2 (ATP2C2 Produkte)

Synonyme: KIAA0703 antikoerper, MGC146612 antikoerper, SPCA2 antikoerper, 1810010G06Rik antikoerper, Spca2 antikoerper, mKIAA0703 antikoerper, ATPase secretory pathway Ca2+ transporting 2 antikoerper, ATPase, Ca++ transporting, type 2C, member 2 S homeolog antikoerper, ATPase, Ca++ transporting, type 2C, member 2 antikoerper, ATP2C2 antikoerper, atp2c2.S antikoerper, atp2c2 antikoerper, Atp2c2 antikoerper

Hintergrund: ATP2C2, also known as secretory pathway Ca2+/Mn2+-ATPase (SPCA) 2, belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium from the cytosol to the Golgi lumen. Defects in the related gene ATP2C1 cause Hailey-Hailey disease, for which ATP2C2 does not compensate, suggesting that ATP2C2 plays other physiological roles. Unlike ATP2C1, ATP2C2 has a much more restricted expression pattern and displays a higher maximal turnover rate for overall Ca2+-ATPase reaction and a lower apparent affinity for cytosolic Ca2+ activation of phosphorylation. Overexpression of ATP2C2 in mammary tumors result a Ca2+ influx via the store-operated Ca2+ channel ORAI1 and independent of the STIM1 and STIM2 sensors.Synonyms: ATP2C2, ATPase 2C2, Calcium-transporting ATPase type 2C member, EC=3.6.3.8, KIAA0703, SPCA2, Secretory pathway Ca(2+)-ATPase 2

Gen-ID: 9914

NCBI Accession: NP_055676

UniProt: O75185

Pathways: Ribonucleoside Biosynthetic Process